天然抗氧化剂在阿尔兹海默病中的应用研究进展

神经药理学报 ›› 2015, Vol. 5 ›› Issue (6): 30-34.

天然抗氧化剂在阿尔兹海默病中的应用研究进展

王莹莹^1,2 宋修云¹ 王奇² 陈乃宏¹

1 中国医学科学院，北京协和医学院药物研究所，北京，100050，中国
2广州中医药大学，临床药理研究所，广州，510000，中国

出版日期:2015-12-26 发布日期:2016-03-03
通讯作者: 陈乃宏，男，博士后，研究员；研究方向：神经药理学和神经分子生物学； Tel: +86-010-63165177，E-mail: chennh@imm.ac.cn
作者简介:王莹莹，女，硕士研究生； E-mail:wangyingyingwangye@163.com
基金资助:
国家自然科学基金项目（NO.81173578, 81273629, 81373997, 21272278）；北京市自然科学基金项目（NO.7131013、7142115）新药作用机制研究与药效评价北京市重点实验室资助项目（BZ0150）

Application of Natural Antioxidants in the Progress of Alzheimer's Disease

WANG Ying-ying ^1,2, SONG Xiu-yun ^1, WANG Qi ², CHEN Nai-hong ¹

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica &Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Guangzhou University of Chinese Medicine, Institute of Clinical Pharmacology, Guangzhou, 510000, China

Online:2015-12-26 Published:2016-03-03
Contact: 陈乃宏，男，博士后，研究员；研究方向：神经药理学和神经分子生物学； Tel: +86-010-63165177，E-mail: chennh@imm.ac.cn
About author:王莹莹，女，硕士研究生； E-mail:wangyingyingwangye@163.com
Supported by:
国家自然科学基金项目（NO.81173578, 81273629, 81373997, 21272278）；北京市自然科学基金项目（NO.7131013、7142115）新药作用机制研究与药效评价北京市重点实验室资助项目（BZ0150）

摘要/Abstract

摘要： 氧化应激极易触发细胞内信号转导，催化神经元变性，导致神经元死亡和丢失，进而引起和加重阿尔茨海默病（Alzheimer's disease，AD），在AD的发生与发展中发挥至关重要的作用。积极的抗氧化措施可预防、延缓和治疗AD。在各种抗氧化干预中，天然抗氧化剂因易摄取，副作用小等特点成为未来AD新药研发的重点之一。本文综述了近年来天然抗氧化剂预防及治疗AD的研究进展。

关键词: 阿尔茨海默病, 氧化应激, 天然抗氧化剂\研究进展

Abstract: Oxidative stress could easily trigger intracellular signal transduction, catalyze neuronal degeneration, lead to neuronal death and loss, thereby cause and aggravate Alzheimer's disease (AD). Oxidative stress plays a crucial role in the occurrence and development of AD. Active antioxidant actions could prevent, delay, and treatment AD. In various antioxidant interventions, natural antioxidants became focus on field of future anti-AD research and development for their easily ingest, side effects and other characteristics. In this paper, the progress of natural antioxidants in AD prevention and treatment was summarized in recent years.

Key words: Alzheimer's disease, oxidative stress, natural antioxidants, research progress

中图分类号:

R964

王莹莹, 宋修云, 王奇, 陈乃宏. 天然抗氧化剂在阿尔兹海默病中的应用研究进展[J]. 神经药理学报, 2015, 5(6): 30-34.

WANG Ying-ying, SONG Xiu-yun, WANG Qi, CHEN Nai-hong. Application of Natural Antioxidants in the Progress of Alzheimer's Disease[J]. Acta Neuropharmacologica, 2015, 5(6): 30-34.

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