神经药理学报 ›› 2014, Vol. 4 ›› Issue (2): 55-64.

• 综述 • 上一篇    

脑缺血再灌注引起多器官损伤的研究进展

赵薇,王树,李方江   

  1. 1. 河北北方学院药学系,张家口,075000,中国
    2. 河北北方学院第一附属医院心血管内科,张家口,075000,中国
  • 出版日期:2014-04-26 发布日期:2014-06-27
  • 通讯作者: 王树,男,副教授,硕士生导师,研究方向:心脑血管损伤研究,Tel: 86-313-4029308,E-mail:wangshu388@163.com 李方江,男,主任医师,硕士生导师,研究方向:心血管疾病研究,E-mail:lfj6789@163.com
  • 作者简介:赵薇,女,硕士研究生,研究方向:心脑血管损伤研究, E-mail:670734978@qq.com
  • 基金资助:

    河北省科技支撑计划项目(No.07276166), 河北北方学院自然科学研究项目(No. 2010022)

Progress in Understanding the Multiple Organ Injury Induced by Cerebral Ischemia-reperfusion

ZHAO Wei, WANG Shu,LI Fang-jiang   

  1. 1. Department of Pharmacy, Hebei North University, Zhangjiakou 075000, Hebei, China
    2. Department of Cardiovascular Medicine, The First Affiliated Hospital, Hebei North University, Zhangjiakou, 075000, Hebei, China
  • Online:2014-04-26 Published:2014-06-27
  • Contact: 王树,男,副教授,硕士生导师,研究方向:心脑血管损伤研究,Tel: 86-313-4029308,E-mail:wangshu388@163.com 李方江,男,主任医师,硕士生导师,研究方向:心血管疾病研究,E-mail:lfj6789@163.com
  • About author:赵薇,女,硕士研究生,研究方向:心脑血管损伤研究, E-mail:670734978@qq.com
  • Supported by:

    河北省科技支撑计划项目(No.07276166), 河北北方学院自然科学研究项目(No. 2010022)

摘要: 急性缺血性脑血管疾病如脑梗死和脑出血等是老年人常见病和多发病,死亡率高。缺血性脑血管疾病患者发病后,可使某些器官功能损伤甚至衰竭,甚至发生多个器官功能损伤、衰竭。各器官功能衰竭加重原有脑部病灶的损伤,并可使机体各器官进一步受累,形成恶性循环,甚至导致死亡。因此开展脑缺血再灌注多器官损伤防治作用的研究,具有重大医学价值和社会意义。本文就脑缺血再灌注引起的心、肺、肝、肾、胃肠、脾等器官损伤和血流动力学变化以及肢体功能障碍等研究进展进行综述,并提出“双向式”的科学研究概念。

关键词: 脑缺血再灌注, 多器官损伤, 血液流变学, 炎症反应, &, ldquo, 双向式&, rdquo, 研究

Abstract: Acute ischemic cerebrovascular diseases such as cerebral infarction and cerebral hemorrhage are common and frequently-occurring diseases among the aged people with high mortality rate. After the attack of the ischemic cerebrovascular disease, some organ function would damage and fail, and even worse the occurrence of multiple organs function damage and failure. The failure of various organs causes the aggravation of the original brain lesions, further leading to aggravated multiple organs dysfunction with the emergence of a vicious spiral and even death. Accordingly, it is important to study the prevention and treatment of the multiple organ injury induced by cerebral ischemia-reperfusion. This review focused on the research progress in understanding organ injury such as heart, lung, liver, kidney, gastrointestinal tract, spleen and other organs, hemodynamic changes, and dysfunction of extremities induced by cerebral ischemia-reperfusion. A novel concept on cerebral ischemia-reperfusion was also discussed.

Key words: cerebral ischemia-reperfusion, multiple organ injury, hemorheology, inflammatory reaction, study by reversible way

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