大黄酚神经保护作用的研究进展及机制探讨

神经药理学报 ›› 2014, Vol. 4 ›› Issue (1): 52-57.

大黄酚神经保护作用的研究进展及机制探讨

颜娟¹ ，张丹参²

1. 河北北方学院附属第一医院药学部，张家口，075000，中国
2. 河北科技大学，石家庄，050018，中国

出版日期:2014-02-26 发布日期:2014-06-06
通讯作者: 张丹参，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail: zhangds2011@126l.com
作者简介:颜娟，女，博士研究生；研究方向：神经药理学；E-mail:zhengmd520@126.com
基金资助:
河北北方学院重大项目(No.ZD201310)，河北省青年科学基金

Protective Effects and Mechanisms of Chrysophanol in the Nervous System

YAN Juan¹, ZHANG Dan-shen²

1. Department of Pharmacy, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China
2. The University of Science and Technology, Shijiazhuang, 050018, China

Online:2014-02-26 Published:2014-06-06
Contact: 张丹参，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail: zhangds2011@126l.com
About author:颜娟，女，博士研究生；研究方向：神经药理学；E-mail:zhengmd520@126.com
Supported by:
河北北方学院重大项目(No.ZD201310)，河北省青年科学基金

摘要/Abstract

摘要： 大黄酚是中药大黄中主要的有效单体之一，属于蒽醌类化合物。研究表明，大黄酚在脑缺血再灌注损伤、阿尔茨海默病中表现出很好的神经保护作用，其机制可能包括：抗氧化，抑制组织中AChE活性，调节脑内氨基酸水平，增强脑组织耐缺氧能力，减轻海马神经元损伤，抑制神经元凋亡等。大黄酚是一种具有广阔应用前景的化合物。本文对大黄酚近年来神经保护作用研究进展作一综述。

关键词: 大黄酚, 抗氧化, 脑缺血再灌注, 神经元凋亡

Abstract: Chrysophanol is an active component of the herbal medicine rhubarb (Rheum palmatum). Many researches have shown that chrysophanol has extensive bioactivity in cerebral ischemia-reperfusion injury and Alzheimer's disease. The neuroprotective mechanisms include antioxidant, AChE activity inhibition, brain amino acid modulation, brain tissue hypoxia tolerance enhancement, hippocampal neuron damage protection and neuronal apoptosis inhibition. It is a compound with a broad application potential. This paper mainly discussed the protective effects and mechanisms of chrysophanol in the nervous system.

Key words: chrysophanol, antioxidant, cerebral ischemia-reperfusion, neuronal apoptosis

颜娟, 张丹参. 大黄酚神经保护作用的研究进展及机制探讨[J]. 神经药理学报, 2014, 4(1): 52-57.

YAN Juan, ZHANG Dan-shen. Protective Effects and Mechanisms of Chrysophanol in the Nervous System[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 52-57.

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