嗜中性白细胞碱性磷酸酶炎症复合体的激活与活性氧之间的关系

摘要/Abstract

摘要： 炎症反应已被证明在脑缺血再灌损伤中扮演了重要角色。炎症复合体（inflammasome）是胞浆中参与非特异性免疫的一种多蛋白复合物，其功能主要为识别外来或内源性的危险信号，进而激活含半胱氨酸的天冬氨酸蛋白水解酶-1（cysteinyl aspartate specific proteinase-1，caspase-1），调节炎症因子如：白介素1b（IL1b）、白介素18（IL18）的表达。目前，在炎症复合体中，研究最广泛的是由嗜中性白细胞碱性磷酸酶-3（neutrophilic alkaline phosphatase-3，NALP3）、凋亡相关点样蛋白（apoptosis-associated speck-like protein，ASC）及caspase-1组成的NALP3炎症复合体。然而，调节其生成和激活的分子机制仍不十分清楚。近期研究显示，被NALP3激活物诱导产生的活性氧 (reactive oxygen species, ROS) 是活化NALP3炎症复合体必要的二级信号。本文就ROS与NALP3炎症复合体激活间的关系进行讨论。

关键词: 嗜中性白细胞碱性磷酸酶-3（NALP3）, 炎症复合体, 活性氧（ROS）, 氧化应激

Abstract: Inflammatory reaction has been proved to play an important role in the cerebral ischemia/reperfusion. Inflammasomes are a family of protein complexes that were recently identified as the cellular machinery responsible for recognizing pathogen-associated molecular patterns and reacting to these through activation of inflammatory processes, such as IL1b and IL18. Among different types of inflammasomes, the neutrophilic alkaline phosphatase-3 (NALP3) inflammasome is the most studied. It is characterized as a proteolytic complex mainly composed of the neutrophilic alkaline phosphatase-3 (NALP3), the adaptor protein apoptosis-associated speck-like protein (ASC), and caspase-1. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent evidence suggests that reactive oxygen species (ROS) are produced by NALP3 activators and are essential secondary messengers signaling NALP3 inflammasome activation. This paper discussed the relationship between ROS and activation of NALP3 inflammasome.

Key words: neutrophilic alkaline phosphatase 3 (NALP3）, inflammasome, reactive oxygen species (ROS), oxidative stress

张楠，张祥建. 嗜中性白细胞碱性磷酸酶炎症复合体的激活与活性氧之间的关系[J]. 神经药理学报, 2013, 3(5): 50-57.

ZHANG Nan, ZHANG Xiang-jian. The Relationship Between reactive oxygen species (ROS) and activation of neutrophilic alkaline phosphatase 3 (NALP3) Inflammasome[J]. Acta Neuropharmacologica, 2013, 3(5): 50-57.

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