Akt信号通路与缺血性脑卒中

神经药理学报 ›› 2012, Vol. 2 ›› Issue (4): 19-27.

Akt信号通路与缺血性脑卒中

胡珺，雷帆，邢东明，杜力军

清华大学生命科学学院医学院药物药理实验室，蛋白质科学教育部重点实验室，北京，100084，中国

出版日期:2012-08-26 发布日期:2014-06-27
通讯作者: 杜力军，男，博士，教授，博士生导师；研究方向：分子药理学；E-mail：lijundu@mail.tsinghua.edu.cn
作者简介:胡珺，男，博士研究生；研究方向：生物化学与分子生物学；E-mail：hujun06@mails.tsinghua.edu.cn
基金资助:
国家自然科学基金项目(No.81374006，No.81073092)，“ 重大新药创制”科技重大专项项目(No.2012ZX09103-201-041，No.2012ZX09102-201-008，No.2011ZX09101-002-11)。

Akt Signaling Pathway and Ischemic Stroke

HU Jun, LEI Fan, XING Dong-ming, DU Li-jun

MOE Key Laboratory of Protein Sciences, Laboratory of Molecular Pharmacology and Pharmaceutical Sciences，School of Life Sciences and School of Medicine， Tsinghua University，Beijing，100084，China

Online:2012-08-26 Published:2014-06-27
Contact: 杜力军，男，博士，教授，博士生导师；研究方向：分子药理学；E-mail：lijundu@mail.tsinghua.edu.cn
About author:胡珺，男，博士研究生；研究方向：生物化学与分子生物学；E-mail：hujun06@mails.tsinghua.edu.cn
Supported by:
国家自然科学基金项目(No.81374006，No.81073092)，“ 重大新药创制”科技重大专项项目(No.2012ZX09103-201-041，No.2012ZX09102-201-008，No.2011ZX09101-002-11)。

摘要/Abstract

摘要： 本文对Akt的生物学以及在缺血性脑卒中的病理生理作用进行了讨论，并介绍了最新的相关研究进展。Akt在脑缺血再灌损伤中呈现高磷酸化表达，对脑组织损伤有保护作用。最新研究提示，Akt具有应激反应的特征，其对脑保护的作用与其它通路的协同启动有关。对Akt的深入研究将有助于对其在脑卒中作用的深入理解，有助于相应药物的研发。

关键词: AKT, 脑卒中, 缺血再灌

Abstract: In this paper, the biology of Akt and its physiological function in ischemic cerebral disease were discussed, and the latest research progress was introduced. Akt is highly expressed in cerebral ischemia- reperfusion injury, and has certain protective effect to this kind of brain damage. Recent research suggests that Akt has many features of stress reaction, and its effect on brain protection is related to its cooperative initiation with other pathways. The in-depth study of Akt will help the understanding of the role of the cerebral apoplexy and for new drug research and development.

Key words: AKT, cerebral stroke, ischemia and reperfusion

中图分类号:

R338

胡珺，雷帆，邢东明，杜力军. Akt信号通路与缺血性脑卒中[J]. 神经药理学报, 2012, 2(4): 19-27.

HU Jun, LEI Fan, XING Dong-ming, DU Li-jun. Akt Signaling Pathway and Ischemic Stroke[J]. Acta Neuropharmacologica, 2012, 2(4): 19-27.

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