姜黄素的神经保护作用研究进展

摘要/Abstract

摘要： 姜黄素(curcumin)是从姜科姜黄属植物的根茎中提取出来的一种黄色植物多酚，已经有多年应用。姜黄素具有抗炎、抗氧化等多种药理作用，可以改善癌症、糖尿病和脑外伤等多种疾病症状。近年来随着对姜黄素研究的深入，发现在神经系统疾病中也有较好的效果，如阿尔茨海默尔病、帕金森病、神经疼痛和神经系统肿瘤等。本文综述了姜黄素神经保护效应及其机制。

关键词: 姜黄素, 神经保护, 神经退行性疾病, 脑缺血再灌注, 神经细胞瘤

Abstract: Curcumin is a low molecular weight polyphenol compound derived from the rhizome of the plant Curcuma longa. Curcumin was reported to have anti-inflammatory，anti-oxidation and other pharmacological effects.In recent years, curcumin has also been shown to be effective in several neurological disorders, such as Alzheimer's disease, Parkinson's disease, neuropathic pain, and neuroblastoma. This paper reviewed the neuroprotective effects and the potential therapeutic mechanisms of curcumin.

Key words: curcumin, neuroprotective, neurodegenerative disease, I/R, neuroblastoma

中图分类号:

R961

赵丽艳，余秀娟，韩天云，张万明. 姜黄素的神经保护作用研究进展[J]. 神经药理学报, 2012, 2(2): 58-64.

ZHAO Li-yan1，YU Xiu-juan1，HAN Tian-yun2，ZHANG Wan-ming1. A Review on the Neuroprotective Effects of Curcumin[J]. Acta Neuropharmacologica, 2012, 2(2): 58-64.

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