神经干细胞与神经药理学

摘要/Abstract

摘要： 神经干细胞（neural stem cells，NSCs）是具有高度自我更新能力、能分化为神经元及胶质细胞的前体细胞。NSCs增殖及分化调控机制的研究对于其治疗神经系统退行性疾病及功能修复具有重大意义。研究表明：神经干细胞的治疗作用包括干细胞的归可巢，定植和激活自体神经干细胞，但更重要的是神经干细胞所分泌的神经细胞调控因子群（neurocyte growth regulatory factors, NGRFs）的药理学作用。深入研究这些因子不但对神经细胞再生及功能重建有重要意义，而且为研究这些因子的药理作用机理及开发大分子新药具有指导意义。

关键词: 神经干细胞, 神经细胞调控因子, 中药, 临床应用

Abstract: Neural stem cells (NSCs) are highly capable of self-renewal, they are the precursor cells for differentiation into neurons and gliocyte. Researches on the mechanisms of NSCs proliferation and differentiation are of great significant for the treatment of degenerative diseases of the nervous system and functional restoration. Research has shown that NSCs have therapeutic effects that include stem cell homing, planting and activation of endogenous NSCs, more importantly, neural stem cells also have the pharmacological effect with neurocyte growth regulatory factors (NGRFs) secretion. In-depth study of these NGRFs will not only has great importance for the nerve cells’ regeneration and functional reconstruction, but also provides guiding significance for the pharmacological mechanism of macromolecular in new drug development.

Key words: neural stem cells (NSCs), neurocyte growth regulatory factors (NGRFs), traditional chinese medicine, clinical application

中图分类号:

R964

李欣，霍玉书. 神经干细胞与神经药理学[J]. 神经药理学报, 2012, 2(2): 48-57.

LI Xin, HUO Yu-shu. Neural Stem Cells with It’s Pharmacology[J]. Acta Neuropharmacologica, 2012, 2(2): 48-57.

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