硝化应激参与介导缺血性脑损伤的研究进展

摘要/Abstract

摘要： 硝化应激（nitrosative stress）指机体对活性氮族（reactive nitrogen species，RNS）的高应激性，主要表现为病理过程中过氧亚硝基阴离子（peroxynitrite，ONOO-）过量生成，从而诱发细胞内蛋白质酪氨酸硝基化等分子事件，并最终导致细胞损伤或凋亡级联反应。缺血性脑损伤病理过程中，硝化应激稳态失衡与血脑屏障及神经血管单元破坏密切关联，近年来以抗硝化应激来进行神经血管保护的药物研究受到关注。通过减少ONOO-生成和清除过多的ONOO-来对抗硝化应激损伤将有可能成为防治缺血性脑血管病的策略之一。

关键词: 硝化应激, 过氧亚硝基阴离子, 缺血性脑损伤, 血脑屏障, 蛋白质酪氨酸硝基化

Abstract: Reactive nitrogen species (RNS) are major mediators of nitrosative stress, which causes protein tyrosine nitration and subsequently facilitates the breakdown of the highly-structured cellular machinery as well as the activation of cell death cascade. This review focuses on peroxynitrite (ONOO-)–mediated nitrosative stress signaling, which is closely associated with endothelial cell injury, cerebral edema and neurovascular damage that disrupt microvascular integrity in stroke. Growing evidence indicates that targeting nitrosative stress may be an important strategy to prevent the vascular complications associated with stroke.

Key words: nitrosative stress, peroxynitrite (ONOO-), brain ischemia, blood brain barrier (BBB), protein tyrosine nitration

中图分类号:

R743，R962.1

黄继云，韩峰. 硝化应激参与介导缺血性脑损伤的研究进展[J]. 神经药理学报, 2011, 1(5): 56-64.

HUANG Ji-yun, HAN Feng. Targeting Nitrosative Stress as a Therapeutic Strategy for Neurovascular Protection in Brain Ischemia[J]. Acta Neuropharmacologica, 2011, 1(5): 56-64.

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