The Blood-Brain Barrier and Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2022.04.006

ACTA NEUROPHARMACOLOGICA ›› 2022, Vol. 12 ›› Issue (4): 58-64.DOI: 10.3969/j.issn.2095-1396.2022.04.006

The Blood-Brain Barrier and Alzheimer’s Disease

LV Xue-ying，ZHANG Zheng，LUO Huan-min

1. Yunkang School of Medicine and Health，Nanfang College，Guangzhou，510970，China 2. Department of Pharmacy，the First Affiliated Hospital of Jinan University，Guangzhou，510630，China 3. Department of Pharmacology， School of Medicine，Jinan University，Guangzhou，510632，China

Online:2022-08-26 Published:2023-08-30

Abstract

Abstract:

Alzheimer’s disease is still a difficult problem in medical field since its discovery. This article reviews the relationship between blood-brain barrier （BBB） and Alzheimer’s disease. A large number of studies have identified elevated BBB leakage in Alzheimer’s disease patients，and ApoE4 is the strongest genetic risk factor for late onset Alzheimer’s disease. This paper focuses on the causes of BBB damage and how to repair BBB to achieve the therapeutic effect of Alzheimer’s disease.

Key words: blood-brain barrier, permeability, Alzheimer’s disease, ApoE4, β-amyloid deposition, microglia, inflammation

LV Xue-ying, ZHANG Zheng, LUO Huan-min. The Blood-Brain Barrier and Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2022, 12(4): 58-64.

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The Blood-Brain Barrier and Alzheimer’s Disease

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