Targeting Nitrosative Stress as a Therapeutic Strategy for Neurovascular Protection in Brain Ischemia

Abstract

Abstract: Reactive nitrogen species (RNS) are major mediators of nitrosative stress, which causes protein tyrosine nitration and subsequently facilitates the breakdown of the highly-structured cellular machinery as well as the activation of cell death cascade. This review focuses on peroxynitrite (ONOO-)–mediated nitrosative stress signaling, which is closely associated with endothelial cell injury, cerebral edema and neurovascular damage that disrupt microvascular integrity in stroke. Growing evidence indicates that targeting nitrosative stress may be an important strategy to prevent the vascular complications associated with stroke.

Key words: nitrosative stress, peroxynitrite (ONOO-), brain ischemia, blood brain barrier (BBB), protein tyrosine nitration

CLC Number:

R743，R962.1

HUANG Ji-yun, HAN Feng. Targeting Nitrosative Stress as a Therapeutic Strategy for Neurovascular Protection in Brain Ischemia[J]. Acta Neuropharmacologica, 2011, 1(5): 56-64.

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