Formaldehyde, an Epigenetic Factor for Learning and Memory Participating In Histone (de)methylation

Abstract

Abstract: Histone methylation or demethylation is a process by which methyl groups are transferred onto or taken off the amino acids of histone proteins. In most cases, methylation and demethylation turn the genes in DNA "off" and "on", a major process in the epigenetic regulation. The covalent modification of histone is closely related to memory formation and forgetting occurrence. Formaldehyde, a methyl group donor, participates in the modification of histone. This suggests that imbalance of formaldehyde metabolism may interfere with histone methylation and demethylation, which is hypothesized as a risk factor involving age-related cognitive impairment including memory loss.

Key words: histone, de-methylation, formaldehyde, epigenetic, cognitive impairment

CLC Number:

R964

LI Ting, SU Tao, HE Ying-ge, HE Rong-qiao. Formaldehyde, an Epigenetic Factor for Learning and Memory Participating In Histone (de)methylation[J]. Acta Neuropharmacologica, 2014, 4(6): 21-27.

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