神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (5): 37-.DOI: 10.3969/j.issn.2095-1396.2024.05.005

• 研究论文 • 上一篇    下一篇

甲泼尼龙与多西环素联合治疗方案用于肺炎支原体肺炎患儿对炎性因子及氧化应激指标的影响

盛文才，周月   

  1. 南通大学第六附属医院盐城市第三人民医院，盐城，224008，中国
  • 出版日期:2024-10-25 发布日期:2024-10-26
  • 通讯作者: 周月，本科，主管护师；研究方向：儿内科
  • 作者简介:盛文才，本科，副主任医师；研究方向：儿内科；E-mail：entice_na@163.com

The Effects of A Combination Therapy of Methylprednisolone and Doxycycline on Inflammatory Factors and Oxidative Stress Indicators in Children with Mycoplasma Pneumoniae Pneumonia

SHENG Wen-cai，ZHOU Yue   

  1. Affiliated Hospital 6 of Nantong University,Yancheng Third People's Hospital, Yancheng, 224008, China
  • Online:2024-10-25 Published:2024-10-26

PDF (PC)

2

摘要：

目的：分析肺炎支原体肺炎（mycoplasma pneumoniae pneumonia，MPP）患儿使用甲泼尼龙与多西环 素联合治疗方案的效果，探讨其对炎性因子、氧化应激指标的影响。方法：选取2021 年5 月至2023 年5 月在 盐城市第三人民医院治疗的200 例MPP 患儿按随机抽样法分为两组研究。对照组（n=100）使用单一多西环 素治疗方案，观察组（n=100）使用甲泼尼龙与多西环素联合治疗方案。比较两组的治疗效果、炎性因子水平、 氧化应激水平、药物不良反应。结果：经过2 周的治疗，治疗效果比较，观察组治疗总有效率高于对照组；炎性 因子水平比较，观察组C 型反应性蛋白（C-reactive protein，CRP）、肿瘤坏死因子-α（tumor necrosis factor-α， TNF-α）、白细胞介素-8（interleukin-8，IL-8）水平均低于对照组；氧化应激水平比较，观察组的脂质过氧化物（lipid peroxidation，LPO）水平更低，而白蛋白(albumin，ALB)、总胆红素(total bilirubin，TBIL) 水平更高；以上比较差 异均具有统计学意义（P<0.05），但药物不良反应比较并无统计学意义（P>0.05）。结论：甲泼尼龙与多西环素联合 治疗方案可有效调节MPP 患儿的炎性因子水平及氧化应激水平，取得显著的治疗效果，且安全性高。

关键词: 肺炎支原体肺炎, 甲泼尼龙, 多西环素, 联合治疗, 炎性因子, 氧化应激

Abstract:

Objective： To analyze the effectiveness of a combination therapy of methylprednisolone and doxycycline in children with Mycoplasma pneumoniae pneumonia and to explore its impact on inflammatory factors and oxidative stress indicators. Methods: A total of 200 children with Mycoplasma pneumoniae pneumonia treated in our hospital from May 2021 to May 2023 were selected and randomly divided into two groups. The control group (n=100) received doxycycline monotherapy, while the observation group (n=100) received a combination therapy of methylprednisolone and doxycycline. The therapeutic effects, levels of inflammatory factors, oxidative stress levels, and adverse drug reactions were compared between the two groups. Results: After a two-week treatment period, the overall effective rate of treatment in the observation group was higher than that in the control group. Levels of inflammatory factors (CRP,TNF-α, IL-8) in the observation group were lower than those in the control group. Oxidative stress indicators showed that LPO levels were lower, while ALB and TBIL levels were higher in the observation group compared to the control group. These differences were statistically significant (P<0.05). However, there was no statistical significance in the comparison of adverse drug reactions between the two groups (P>0.05). Conclusion: The combination therapy of methylprednisolone and doxycycline effectively regulates the levels of inflammatory factors and oxidative stress indicators in children with Mycoplasma pneumoniae pneumonia, achieving remarkable therapeutic effects with high safety.

Key words: mycoplasma pneumoniae pneumonia, methylprednisolone, doxycycline, combination therapy, inflammatory factors, oxidative stress

中图分类号: