肾上腺髓质素在心、肺相关性疾病中的研究进展

doi:10.3969/j.issn.2095-1396.2019.01.006

摘要/Abstract

摘要：

肾上腺髓质素（adrenomedullin，ADM）是一种舒血管活性多肽物质，共由52 个氨基酸组成，其主要特点为第16 位与21 位半胱氨酸残基间由二硫键连接。它在心、肺等重要器官中具有高水平表达，其合成、分泌的主要部位为血管内皮细胞和平滑肌细胞，其中内皮细胞占主导地位。ADM 具有舒张血管、降压、利尿、抗炎、参与氧化应激、抑制平滑肌细胞增殖、迁移、分化等多种作用，在心肺相关性疾病中具有诸多研究，该文综述了ADM 在心、肺相关性疾病中的研究进展，以期为临床治疗提供新思路。

关键词: 肾上腺髓质素, 心肺疾病, 研究进展

Abstract:

Adrenomedullin （ADM） is a vasodilator active polypeptide consisting of 2 amino acids. Its main characteristic is that the 16th and 21st cysteine residues are linked y disulfide bonds. It is highly expressed in heart，lung and other important organs. The main arts of synthesis and secretion are vascular endothelial cells and smooth muscle cells，in which ndothelial cells play a dominant role. It has many functions，such as vasodilation，hypotension， iuresis，anti-inflammation，participation in oxidative stress，inhibition of smooth muscle cell roliferation，migration and differentiation，etc. It has many studies in cardiopulmonary-related iseases. This article reviews the research progress of ADM in cardiopulmonary-related diseases， n order to provide new ideas for clinical treatment.

中图分类号:

R966

郭沫然，周城伟，张志华. 肾上腺髓质素在心、肺相关性疾病中的研究进展[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2019.01.006.

GUO Mo-ran，ZHOU Cheng-wei，ZHANG Zhi-hua. Progress of Adrenomedullin in Cardiopulmonary Related Diseases[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.01.006.

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