血脑脊液屏障RAGE/LRP1转运体及神经血管单元与阿尔茨海默病关系的研究进展

神经药理学报 ›› 2015, Vol. 5 ›› Issue (2): 38-45.

血脑脊液屏障RAGE/LRP1转运体及神经血管单元与阿尔茨海默病关系的研究进展

王浩，杜贯涛，刘广军，洪浩

1. 中国药科大学药理教研室，南京，210009，中国
2. 南京医科大学附属常州市第二人民医院药学部，常州，213003，中国

出版日期:2015-04-26 发布日期:2015-07-06
通讯作者: 洪浩，男，博士，教授，博士生导师；研究方向：神经与内分泌药理；Tel：+86-025-86185227，E-mail：honghao@cpu.edu.cn
作者简介:王浩，男，硕士研究生；研究方向：神经药理学；Tel：+86-025-86185227，E-mail：wanghao890625@126.com
基金资助:
国家自然科学基金面上项目（No. 81273497）

Research Progress on RAGE/LRP1 Transporters At the Blood-Brain Barrier and the Neurovascular Unit in Alzheimer’s Disease

WANG Hao, DU Guan-tao, LIU Guang-jun, HONG Hao

1. Department of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China
2. Department of Pharmacy, Nanjing Medical University Subsidiary Changzhou No.2 People’s Hospital, Changzhou, 213003, China

Online:2015-04-26 Published:2015-07-06
Contact: 洪浩，男，博士，教授，博士生导师；研究方向：神经与内分泌药理；Tel：+86-025-86185227，E-mail：honghao@cpu.edu.cn
About author:王浩，男，硕士研究生；研究方向：神经药理学；Tel：+86-025-86185227，E-mail：wanghao890625@126.com
Supported by:
国家自然科学基金面上项目（No. 81273497）

摘要/Abstract

摘要： 血脑脊液屏障（blood cerebrospinal fluid barrier，blood-CSF barrier）是介于外周和中枢神经系统之间的一道生理屏障，对维持中枢神经系统的稳态起着重要作用。研究表明，血脑脊液屏障与阿尔茨海默病（Alzheimer’s disease，AD）的发生发展密切相关。本文重点论述血脑脊液屏障晚期糖基化终产物受体（receptor for advanced glycation end products，RAGE）/低密度脂蛋白受体相关蛋白1（low density lipoprotein receptor-related protein 1，LRP1）受体转运系统及以血脑脊液屏障为核心组分的神经血管单元（neurovascular unit，NVU）介导的中枢β-淀粉样蛋白（β-amyloid protein，Aβ）水平调控与AD发病机制的关系，为AD防治提供新思路。

关键词: 血脑脊液屏障, &, beta, -淀粉样蛋白, 阿尔茨海默病, RAGE/LRP1受体转运系统, 神经血管单元

Abstract: The blood cerebrospinal fluid barrier (blood-CSF barrier) existed between peripheral and central nervous system (CNS) plays critical roles in the maintenance of CNS homeostasis. Emerging evidence suggests that blood-CSF barrier is closely related to the development and pathogenesis of Alzheimer’s disease (AD). This review discusses the role of receptor for advanced glycation end products (RAGE), low density lipoprotein receptor-related protein 1 (LRP1) transporters, and the neurovascular unit (NVU) mediated central β-amyloid protein regulation in the pathogenesis of AD, providing new prevention and treatment strategies for AD.

Key words: blood cerebrospinal fluid barrier (blood-CSF barrier), &, beta, -amyloid protein (A&, beta, ), Alzheimer&, rsquo, s disease (AD), RAGE/LRP1 transporters, neurovascular unit

王浩，杜贯涛，刘广军，洪浩. 血脑脊液屏障RAGE/LRP1转运体及神经血管单元与阿尔茨海默病关系的研究进展[J]. 神经药理学报, 2015, 5(2): 38-45.

WANG Hao, DU Guan-tao, LIU Guang-jun, HONG Hao. Research Progress on RAGE/LRP1 Transporters At the Blood-Brain Barrier and the Neurovascular Unit in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2015, 5(2): 38-45.

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