肢体远端缺血后适应减少SD大鼠脑缺血再灌注损伤

神经药理学报 ›› 2014, Vol. 4 ›› Issue (4): 10-14.

肢体远端缺血后适应减少SD大鼠脑缺血再灌注损伤

蒲举, 姚声涛

1.南充市中心医院，南充，637100，中国
2.遵义医学院附属医院脑血管病科，遵义，563000，中国

出版日期:2014-08-26 发布日期:2015-01-20
通讯作者: 姚声涛，医学博士，教授，硕士生导师；E-mail：610797973@qq.com
作者简介:蒲举，硕士研究生
基金资助:
遵义市科技局与遵义医院科技合作项目（NO.2010017）

Effects of Limb Remote Ischemic Postconditioning on Cerebral Ischemia-Reperfusion Injury

PU Ju, YAO Sheng-tao

1. Nanchong Central Hospital, Nanchong, 637100, China
2. Department of Cerebral Vascular Diseases, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000, China

Online:2014-08-26 Published:2015-01-20
Contact: 姚声涛，医学博士，教授，硕士生导师；E-mail：610797973@qq.com
About author:蒲举，硕士研究生
Supported by:
遵义市科技局与遵义医院科技合作项目（NO.2010017）

摘要/Abstract

摘要： 目的：研究肢体远端缺血后适应（limb remote ischemic postconditioning，RIP）对脑缺血再灌注损伤的影响。方法：建造大脑中动脉闭塞模型，予以双下肢远隔缺血后适应，采用Bederson评分法对雄性SD大鼠脑缺血后12 h，24 h，72 h进行评分，运用磁共振T2加权像（T2-Weighted Imaging，T2WI）计算梗死体积。结果：RIP组大鼠24 h后Bederson评分较再灌注模型组评分减少，差异有统计学意义（P<0.05），据T2WI算得RIP组脑梗死体积在12 h，24 h，72 h均较再灌注模型组减少，差异有统计学意义（P<0.05）。结论：RIP减少缺血后24h神经功能评分，减少梗死体积，具有减轻再灌注损伤作用。

关键词: 远隔缺血后适应, 再灌注损伤, 神经功能评分

Abstract: Objective: To study the effects of limb remote ischemic postconditioning (RIP) on reducing brain damage in cerebral ischemia-reperfusion. Methods: Ischemia-reperfusion injury and remote ischemic postconditioning models were established in rats. The neurological deficit scores were assessed (Bederson score) at 12, 24, and 72 hours post-surgeries. T2-Weighted Imaging of magnetic resonance imaging(MRI) was used to determine the infarct volume at 12 hours,24 hours,72 hours. Results: Compared with the model groups, the neurological deficit scores were decreased in 24h groups (P<0.05).The volume of infraction in RIP groups was significantly smaller than those in the model groups after ischemia at each time point. Conclusion: RIP reduces the neurological deficit scores at 24h after ischemia, alleviates the volume of cerebral infraction from 12h to 72h after ischemia, suggesting that RIP can decrease cerebral ischemia reperfusion injury.

Key words: Ischemic postconditioning, Ischemia-reperfusion, Neurological deficit scores

中图分类号:

R965

蒲举, 姚声涛. 肢体远端缺血后适应减少SD大鼠脑缺血再灌注损伤[J]. 神经药理学报, 2014, 4(4): 10-14.

PU Ju, YAO Sheng-tao. Effects of Limb Remote Ischemic Postconditioning on Cerebral Ischemia-Reperfusion Injury[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(4): 10-14.

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