吸入麻醉药对组织器官缺血再灌注损伤的保护作用

神经药理学报 ›› 2013, Vol. 3 ›› Issue (1): 28-36.

吸入麻醉药对组织器官缺血再灌注损伤的保护作用

李英杰，杨宝学

天然药物及仿生药物国家重点实验室，北京大学基础医学院药理学系，北京，100191，中国

出版日期:2013-02-26 发布日期:2014-06-27
通讯作者: 杨宝学，男，1962，教授，博士，博士生导师，中国药理学会理事；Tel：+86-010-828256222，E-mail: baoxue@bjmu.edu.cn
作者简介:李英杰，男，硕士研究生，药理学；Tel：+86-010-82805559，E-mail: liyingjiecuihuimei@163.com
基金资助:
国家自然科学基金(No.30870921、No.81170632、No.81261160507)，科技部国际科技合作与交流专项（No.2012DFA11070），教育部高等学校博士学科点专项科研基金(No.20100001110047)

Protective Effects of Volatile Anesthetics on Organ Ischemia-Reperfusion Injury

LI Ying-jie，YANG Bao-xue

State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191,China

Online:2013-02-26 Published:2014-06-27
Contact: 杨宝学，男，1962，教授，博士，博士生导师，中国药理学会理事；Tel：+86-010-828256222，E-mail: baoxue@bjmu.edu.cn
About author:李英杰，男，硕士研究生，药理学；Tel：+86-010-82805559，E-mail: liyingjiecuihuimei@163.com
Supported by:
国家自然科学基金(No.30870921、No.81170632、No.81261160507)，科技部国际科技合作与交流专项（No.2012DFA11070），教育部高等学校博士学科点专项科研基金(No.20100001110047)

摘要/Abstract

摘要： 吸入麻醉药因其安全、可靠、稳定、易于控制等特性，广泛应用于临床全麻手术中。近年来研究表明，吸入麻醉药可以通过减轻细胞损伤，降低梗死面积等方式在分子和细胞水平对脑、心脏、肝脏、肾脏等多器官的缺血再灌注损害起到一定的保护作用。吸入麻醉药可通过激活离子通道、抑制细胞凋亡、基因调控、减少自由基产生等多种途径发挥保护作用。本文综述了吸入麻醉药对机体脏器的保护作用及其机制，对于手术中合理使用麻醉药及预防缺血再灌注损伤具有理论意义。

关键词: 吸入麻醉药, 缺血再灌注, 中枢神经系统, 保护机制

Abstract: Volatile anesthetics are widely used in general anesthesia because of their favorable properties, such as safety, reliability, stability and easily controllable. Recent studies have revealed that volatile anesthetics have protective effects on a variety of organs such as brain, heart, liver, kidney after ischemia/reperfusion at molecular and cellular levels by reducing cell damages and infarction area. In this review article, we summarize the protective effects of volatile anesthetics on the organs and discuss the mechanisms of the protective action. Volatile anesthetic can play protective roles by activating ion channels, inhibiting cell apoptosis, regulating genes, reducing the free radicals. This article lays a theoretical foundation for the reasonable application of anesthetics during operations and reducing ischemia reperfusion injury.

Key words: volatile anesthetic, ischemia reperfusion, central nervous system, protection mechanisms

李英杰，杨宝学. 吸入麻醉药对组织器官缺血再灌注损伤的保护作用[J]. 神经药理学报, 2013, 3(1): 28-36.

LI Ying-jie，YANG Bao-xue. Protective Effects of Volatile Anesthetics on Organ Ischemia-Reperfusion Injury[J]. Acta Neuropharmacologica, 2013, 3(1): 28-36.

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