成年海马神经再生与阿尔茨海默病关系的研究进展

摘要/Abstract

摘要： 海马神经再生持续于哺乳动物整个成年期。在生理刺激以及脑外伤等病理因素的刺激下，神经干细胞可发生增殖、迁移、分化，最终整合到神经元网络中。阿尔茨海默病（Alzheimer^,s disease，AD）是一种中枢神经系统退行性疾病，主要病理学特征为细胞内外β淀粉样蛋白（β-amyloid peptide, Aβ）沉积、细胞内神经原纤维缠结（neurofibrillary tangles, NFT），以及由这些引发的神经元变性、坏死。目前，应用海马神经再生治疗AD已成为极具潜力的治疗手段。该文综述了最近成年海马神经再生与AD关系的研究进展。

关键词: 海马, 神经再生, 阿尔茨海默病

Abstract: Neurogenesis occurs throughout the adulthood in mammals, which involves neural stem cell proliferation, migration, differentiation and integration into the circuits. Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized in the brain by amyloid plaque deposits, neurofibrillary tangles and neuronal loss. In recent years, evidence indicates that adult hippocampal neurogenesis provides new opportunities for the treatment for AD. Here we review recent progress on the relationship between adult hippocampal neurogenesis and AD.

Key words: hippocampus, neurogenesis, Alzheimer's disease

中图分类号:

R338

何娜，殷明，王泽剑. 成年海马神经再生与阿尔茨海默病关系的研究进展[J]. 神经药理学报, 2013, 3(6): 25-32.

HE Na, YIN Ming, WANG Ze-jian. Progress in the Relationship of Adult Hippocampal Neurogenesis and Alzheime’s Disease[J]. Acta Neuropharmacologica, 2013, 3(6): 25-32.

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