Objective：To study the protective effect of Huangjiaruangan granule on the acute liver injury induced by D-galactosamine （D-Gal N） and the liver fibrosis induced by Con A. Methods：Test method for protective effect of acute liver injury：Eighty-four ICR mice were randomly divided into negative control group，model group，positive drug group，and high-dose， medium-dose and low-dose huangjiarangan granule groups. The negative control group and model group were given the same volume of deionized water by intragastric administration，once a day for 14 consecutive days. On day 13 after administration，all animals except the negative control group were intraperitoneally injected with D-Gal N to establish acute liver injury model. Blood samples were collected and necrotized 60 minutes after the last administration. Test method for protective effect of liver fibrosis：96 BALB/ c mice were randomly divided into negative control group，model group，positive drug group，Huangjiarangan granule high-dose，medium-dose and low-dose groups. Animals except the negative control group were injected with Con A according to tail vein，and animals in the negative control group were injected with sterile PBS of the same volume，once a week，7 times in total. On the day of the fourth injection，each group was given intragastric administration，once a day，for 4 weeks. The negative control group and the model group were given intragastric administration of the same volume of deionized water. Blood samples were collected and examined 24 hours after the last injection. Serum ALT and AST were measured in both tests，liver and spleen were collected and weighed to calculate organ index，and pathological changes of liver tissues were observed. Results：In the protective effect test of acute liver injury，the serum ALT and AST of each administration group were significantly lower than that of the model group，and the spleen index of each administration group was significantly reduced，and the degree of liver injury was significantly reduced. In the liver fibrosis protective effect test，the serum ALT and AST in Huangjiaruangan granules high-dose and medium-dose groups were significantly lower than that in the model group，and the liver index in the mediumdose group was significantly lower. Conclusion：Huangjiaruangan granule has a certain protective effect on acute liver injury and liver fibrosis in mice.