小胶质细胞在糖尿病神经病理性疼痛中作用的研究进展

doi:10.3969/j.issn.2095-1396.2016.03.008

摘要/Abstract

摘要： 糖尿病神经病理性疼痛（diabetic neuropathic pain，DNP）是糖尿病患者中最常见的慢性并发症之一。DNP 的发病机制错综复杂，是疼痛医学研究的热点和难点。近年来，脊髓小胶质细胞在 DNP 中的作用越来越多的受到研究者的关注。该文对小胶质细胞生理、病理特性及小胶质细胞在 DNP 中作用的相关受体及信号途
径加以综述，为 DNP 的治疗及药物研究提供理论基础。

关键词: 小胶质细胞, 糖尿病神经病理性疼痛, 受体, 活化, 极化

Abstract: Diabetic neuropathic pain （DNP） is one of the common chronic complications in patients with diabetes mellitus. Because of the complexity of its pathogenesis，the e xact causes of DNP are still unclear. In recent years，the role of microglia in DNP is concerned by researchers. In this review，we discussed the physiological and pathological characteristics of microglia. In addition，the related receptors and signaling pathways of microglia under DNP
condition were also reviewed. These insights provide a basis for new therapeutic approaches.

Key words: microglia, diabetic neuropathic pain, receptor, activation, polarization

洪丽绵, 金桂林, 储美美, 俞昌喜. 小胶质细胞在糖尿病神经病理性疼痛中作用的研究进展[J]. 神经药理学报, 2016, 6(3): 56-64.

HONG Li-mian, JIN Gui-lin, CHU Mei-mei, YU Chang-xi. A Review on the Role of Microglia in Diabetic Neuropathic Pain[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(3): 56-64.

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