氯离子通道研究进展

神经药理学报 ›› 2015, Vol. 5 ›› Issue (4): 33-42.

氯离子通道研究进展

刘雅妮，张会然，赵晨，黄东阳，杜雨薇，张海林

1. 河北医科大学药理教研室，石家庄，050017，中国
2. 北京军事医学科学院军事认知与脑科学中心，北京，100850，中国
3. 河北医科大学第二医院呼吸科，石家庄，050000，中国

出版日期:2015-08-26 发布日期:2016-03-03
通讯作者: 张海林，男，博士，教授，博士生导师；研究方向：分子药理学；Tel: +86-0311-86265562, E-mail: zhanghl@hebmu.edu.cn
作者简介:刘雅妮，女，博士，助理研究员；研究方向：神经生物学；Tel:+86-010-55498798, E-mail: liu-yani@live.cn
基金资助:
国家自然科学基金资助项目（No. 31270882），国家重点基础研究发展计划（973计划）（2013CB531302）

The Progress on Studies of Chloride Channels

LIU Ya-ni, ZHANG Hui-ran, ZHAO Chen, HUANG Dong-yang, DU Yu-wei, ZHANG Hai-lin

1. Pharmacology Department , Hebei Medical University, Shijiazhuang, 050017, China
2. Center of Military Cognition And Brain Science, Academy of Military Medical Sciences, Beijing, 100850, China
3. Department of Respiratory Medicine, The second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

Online:2015-08-26 Published:2016-03-03
Contact: 张海林，男，博士，教授，博士生导师；研究方向：分子药理学；Tel: +86-0311-86265562, E-mail: zhanghl@hebmu.edu.cn
About author:刘雅妮，女，博士，助理研究员；研究方向：神经生物学；Tel:+86-010-55498798, E-mail: liu-yani@live.cn
Supported by:
国家自然科学基金资助项目（No. 31270882），国家重点基础研究发展计划（973计划）（2013CB531302）

摘要/Abstract

摘要： 氯离子是体内最重要最丰富的阴离子, 它进出细胞的过程, 除了与氯离子相关的一些转运体主动转运外, 经过阴离子通道进行转运是重要方式之一。氯离子通道组织分布广泛，参与了众多的生理过程：包括细胞体积的调节、膜电位的稳定性调节、信号转导以及跨上皮运输等。文章重点综述了钙激活氯通道和容积调节氯通道的生理功能及分子基础，简单介绍了电压门控氯通道、囊性纤维跨膜电导转运体及配体门控氯通道。

关键词: 氯离子, 通道, 钙激活氯通道, TMEM16A, Bestrophin1, 容积调节氯通道

Abstract: Chloride is the most abundant anion in all organisms. Chloride channel, besides some active transporters, is one of the important pathways which allow chloride to go through the cell membrane. Chloride channels are probably present in every cell, from bacteria to mammals. Their physiological tasks include but not limited to cell volume regulation, stabilization of the membrane potential, signal transduction and transepithelial transporting. This review focus on the physiological functions and molecular identity of calcium activated chloride channels and volume regulated chloride channels, and also review briefly on voltage gated chloride channels, cystic fibrosis transmembrane conductance regulator and ligand gated chloride channels.

Key words: Chloride ion, channel, calcium activated chloride channels(CaCCs), TMEM16A, Bestrophin1, volume regulated chloride channels

刘雅妮，张会然，赵晨，黄东阳，杜雨薇，张海林. 氯离子通道研究进展[J]. 神经药理学报, 2015, 5(4): 33-42.

LIU Ya-ni, ZHANG Hui-ran, ZHAO Chen, HUANG Dong-yang, DU Yu-wei, ZHANG Hai-lin. The Progress on Studies of Chloride Channels[J]. Acta Neuropharmacologica, 2015, 5(4): 33-42.

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