神经系统中丝裂原活化蛋白激酶磷酸酶-1的研究进展

摘要/Abstract

摘要： 丝裂原活化蛋白激酶磷酸酶-1（mitogen-activated protein kinase phosphatase-1，MKP-1）作为生物体内重要的信号转导系统——丝裂原活化蛋白激酶系统（mitogen-activated protein kinases，MAPKs）去磷酸化的重要调节者，在包括神经系统的各种生物学系统中发挥重要作用。本文对MKP-1的生物学活性、调控以及在神经系统中的作用进行综述，以期为MKP-1作为药理学靶点的相关研究提供新思路。

关键词: MKP-1, MAPKs, 去磷酸化, 转录, 突触可塑性, 抑郁, 神经炎症

Abstract: As a major regulator of dephosphorylation of mitogen-activated protein kinases (MAPKs) which are importantsignal transduction pathways in organisms, mitogen-activated protein kinase phosphatase-1(MKP-1) plays a crucial role in
various biological systems, including nervous system.This paper summarized the biological activity, regulation, new results and progress of MKP-1 in recent years, with a focus on the central nervous system. We proposed that MKP-1 is a drug target for future pharmacological research.

Key words: MKP-1, MAPKs, dephosporylation, transcription, synaptic plasticity, repression
CNS inflammation

王琦王弘凯冉建华. 神经系统中丝裂原活化蛋白激酶磷酸酶-1的研究进展[J]. 神经药理学报, 2014, 4(1): 58-64.

WANG Qi, WANG Hong-kai, RAN Jian-hua. The Progress of Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in Nervous System[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 58-64.

参考文献

[1] Paul S Shapiro, Natalie G Ahn. Feedback regulation of raf-1 and mitogen-activated protein(MAP)kinase kinases 1 and 2 by map kinase phosphatase-1(MKP-1)[J].Biol Chem, 1998, 273(3)：1788-1793.

[2] G L Johnson, R Lapadat. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases[J].Science, 2002, 298(5600)：1911-1912.

[3] Shinri Tamura, Masahito Hanada, Motoko Sasaki, et a1.Regulation of stress—activated protein kinase signaling pathways by protein phosphatases[J].Eur J Biochem, 2002, 269(4)：1060-1066.

[4] Tarek Boutros, Eric Chevet, Peter Metrakos. Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer[J]. Pharmacol Rev, 2008, 60(3):261–310.

[5] Montesrrat Camps, Anton Nichols, Steve Arkinstall. Dual specificity phosphatases: a gene family for control of MAP kinase function[J]. Faseb, 2000, 14(1):6–16.

[6] Andres Alonso, Joanna Sasin, Nunzio Bottini, et al. Protein tyrosine phosphatases in the human genome[J]. Cell, 2004, 117(6):699–711.

[7] Aspasia Theodosiou, Alan Ashworth. MAP kinase phosphatases[J]. Genome Biol, 2002, 3(7):3009.

[8] Amjad Farooq, Zhou Ming-ming. Structure and regulation of MAPK phosphatases[J]. Cell Signal, 2004, 16(7):769–779.

[9] Mashael Al-Mutairi, Sameer Al-Harthi, Laurence Cadalbert, et al. Overexpression of mitogen-activated protein kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells[J]. Br J Pharmacol, 2012, 161(4):782–798.

[10] Chi Hong-bo, Sean P Barry, Rachel J Roth, et al. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses[J]. PNAS, 2006, 103(7):2274–2279

[11] Samia Reffas, Werner Schlegel. Compartment-specific regulation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs) by ERK-dependent and non-ERK-dependent inductions of MAPK phosphatase (MKP)-3 and MKP-1 in differentiating P19 cells[J]. J Biochem, 2000, 352(Pt 3):701–708.

[12] D M Owens, S M Keyse. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases[J]. Oncogene, 2007, 26(22):3203–3213.

[13] Lyn M Wancket, W Joshua Frazier, Liu Yu-sen. Mitogen-activated protein kinase -1 (MKP-1) in immunology, physiology, and disease[J]. Life Sci, 2012, 90(7-8):237-248.

[14] Tarek Boutres, Eric Chevet, Peter Metrakos. Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth,Death, and Cancer[J] Pharmacol Rev, 2008, 60:261–310.(与第4条重复)

[15] David N Slack, Ole-Morten Seternes, Mads Gabrielsen, et al. Distinct binding determinants for erk2/p38alpha and jnk map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1 [J]. Biol Chem, 2001, 276(19):16491–16500.

[16] Dorothy Hutter, Chen Pei-li, Janice Barnes, et al. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation[J]. Biochem J, 2000, 352(Pt 1):155–163.

[17] Cao Wang-sen, Clare Bao, Elizaveta Padalko, et al. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling [J]. Exp Med, 2008, 205(6):1491–1503.

[18] Dorothy Hutter, Pei-li Chen, Janice Barnes, et al. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation[J]. Biochem, 2000, 352(Pt 1):155–163.(与18重复)

[19] David N Slack, Ole-Morten Seternes, Mads Gabrielsen, et al. Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1[J]. J Biol Chem, 2001, 276(19):16491–1500.（与15重复）

[20] Liu Yusen, Myriam Gorospe, Yang Chun-lin, et al. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation [J] . J Biol Chem, 1995, 270(15):8377–8380.

[21] Sun Hong, Catherine H Charles, Lester F Lau, et al. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo[J]. Cell, 1993, 75(3):487–493.

[22] Ester Sanchez-Tillo, Monica Comalada, Jordi Xaus, et al. JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharidedependent activation[J]. J Biol Chem, 2007, 282(17):12566–12573.

[23] Yukio Hiroi, Junko Hiroi, Suniyo Kudoh, et al. Two distinct mechanisms of angiotensin IIinduced negative regulation of the mitogen-activated protein kinases in cultured cardiac myocytes[J]. Hypertens Res, 2001, 24(4):385–94.

[24] Yuki Kuwano, Hyeon Ho Kim, K Abdelmohsen, et al. MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90[J]. Cell Biol, 2008, 28(14):4562–4575.

[25] Zhu Qing-Yuan, Liu Qin, Chen Jian-Xia, et al. MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages [J]. Immunol, 2010, 185(12):7435–7442.

[26] T Noguchi, R Metz, L Chen, et al. Structure,mapping, and expression of erp, a growth factor-inducible gene encoding a nontransmembrane protein tyrosine phosphatase, and effect of ERP on cell growth[J].Mol Cell Biol, 1993, 13(9):5195–5205.

[27] Lin Yun-Wei, Chuang Show-Mei, Yang Jia-Ling. ERK1/2 achieves sustained activation by stimulating MAPK phosphatase-1 degradation via the ubiquitin-proteasome pathway [J]. J Biol Chem, 2003, 278(24):21534–21541.

[28] Hideaki Kamata, Shi-ichi Honda, Shin Maeda, et al. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases[J]. Cell, 2005, 120(5):649–661.

[29] Linda A Tephly, A Brent Carter. Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression[J]. Cell Mol Biol, 2007, 37(3):366–374.

[30] Zhuo Qian, Mary Gilbert, Eric R Kandel. Temporal and spatial regulation of the expression of BAD2, a MAP kinase phosphatase, during seizure, kindling and long-term potentiation [J]. Learn Mem, 1994, 1(3):180-188.

[31] Haruhito Horita, Kazuhiro Wada, Miriam V Rivas, et al. The dusp1 immediate early gene is regulated by natural stimuli predominantly in sensory input neurons[J] . Comp Neurol, 2010, 518(14):2873-2901.

[32] Chen Mei-feng, Hsiun-Ing Chen, Chauying J Jen. Exercise training upregulates macrophage MKP-1 and affects immune responses in mice [J]. Med Sci Sports Exerc, 2010, 42(12):2173-2179.

[33] Masao Doi, Sehyung Cho, Irene Yujnovsky, et al. Light-inducible and clock-controlled expression of MAP kinase phosphatase1 in mouse central pacemaker neurons [J].Biol Rhythms, 2007, 22(2):127-139.

[34] Freddy Jeanneteau, Katrin Deinhardt. Fine-tuning MAPK signaling in the brain: the role of MKP-1[J]. Commun Integr Biol, 2011, 4(3):281–283.

[35] C Glorioso, M Sabatini, T Unger, et al. Specificity and timing of neocortical transcriptome changes in response to BDNF gene ablation during embryogenesis or adulthood[J] .Mol Psychiatry, 2006, 11(7):633-48.

[36] Cecilia Conde, Alfredo Caceres. Microtubule assembly, organization and dynamics in axons and dendrites[J]. Nat Rev Neurosci, 2009, 10:319-332.

[37] Emmanuel Valjent, Jocelyne Caboche, Pater Vanhoutte. Mitogen-activated protein kinase/extracellular signal-regulated kinase induced gene regulation in brain[J]. Mol Neurobiol, 2001, 23(2):83–99.

[38] Vanja Duric, Mounira Banasr, Pawel Licznerski, et al. A negative regulator of MAP kinase causes depressive behavior [J]. Nat Med, 2010, 16(11): 1328–1332.

[39] Mark Kristiansen, Rosie Hughes, Pritika Patel, et al. Mkp1 is a c-Jun target gene that antagonizes JNK dependent apoptosis in sympathetic neurons [J]. Neurosci, 2010, 30(32): 10820–10832.

[40] Eva Eljaschewitsch, Anke Witting, Christian Mawrin, et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells[J]. Neuron, 2006, 49(1):67–79.

[41] Zhang Yong-liang, Joseph Reynolds, Seon Hee Chang, et al. MAP kinase phosphatase 1 is necessary for T cell activation and function [J]. Biol Chem, 2009, doi: 10.1074/jbc.M109.052472.

[42] Christian Ndong, Russell P Landry, Joyce A DeLeo, et al. Mitogen activated protein kinase phosphatase-1 prevents the development of tactile sensitivity in a rodent model of neuropathic pain[J]. Molecular Pain, 2012, 8:34.

[43] David M Taylor, Roger Moser, Etienne Regulier, et al. MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington’s disease via additive effects of JNK and p38 inhibition[J]. J Neurosci, 2013, 33(6):2313–2325.

[44] Louise M Collins, Gerard W O Keeffe, Caitriona M Long-Smith, et al. Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons[J]. Neuromolecular Med, 2013, 15(2):435–446.

[45] Jaekyoon Kim, Jiyoung Kim, Jaesung Shim, et al. Licorice-derived dehydroglyasperin C increases MKP-1 expression and suppresses inflammation-mediated neurodegeneration [J]. Neurochem Int, 2013, 63(8):732-740 .

[46] Marina A Lynch. Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1b[J]. Prog Neurobiol, 1998, 56(5): 571–589.

[47] Shunsuke Koga, Shunsuke Kojima, Takashi Kishimoto. Over-expression of map kinase phosphatase-1 (MKP-1) suppresses neuronal death through regulating JNK signaling in hypoxia/re-oxygenation[J].Brain Reach, 2012, 1436:137–146.

[48] Russell P Landry, Elena Martinez, Joyce A DeLeo, et al. Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain[J]. J Pain, 2012, 13(9): 836–848.

[49] Ryan J Cady, Jennifer E Denson, Paul L Durham. Inclusion of cocoa as a dietary supplement represses expression of inflammatory proteins in spinal trigeminal nucleus in response to chronic trigeminal nerve stimulation [J]. Mol Nutr Food Res, 2013, 57(6): 996–1006.

[50] Chen Mei-Feng, Huang Tung-Yi, Kuo Yu-Min, et al. Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice[J]. J Physiol, 2013, 591(Pt 4):985–1000.