长时程增强现象与中枢受体

神经药理学报 ›› 2012, Vol. 2 ›› Issue (5): 45-50.

长时程增强现象与中枢受体

董晓华¹ 孟宪勇² 张丹参³

1. 河北北方学院药学系，张家口，075000，中国
2. 河北北方学院附属第一医院，张家口，075000，中国
3. 河北科技大学，石家庄，050018，中国

出版日期:2012-10-26 发布日期:2014-06-27
通讯作者: 张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail：zhangds2011@126.com
作者简介:董晓华，女，副教授，博士；研究方向：神经药理学；Tel：+86-0313-4029305，E-mail：hbdxh76@163.com
基金资助:
河北省科技厅资助项目（No.13272704D），河北省卫生厅资助项目（No.20090183），河北北方学院自然基金项目（No.2009033），河北省张家口市科技局项目（No.0921098D）

Long-term Potentiation and Central Receptors

DONG Xiao-hua¹, MENG Xian-yong², ZHANG Dan-shen³

1. Department of pharmacy, Hebei North University,Zhangjiakou, 075000, China
2. The First Attached Hospital, Hebei North University, Zhangjiakou, 075000, China
3. The University of Science and Technology, Shijiazhuang, 050018, China

Online:2012-10-26 Published:2014-06-27
Contact: 张丹参，女，教授，博士生导师；研究方向：神经药理学；Tel：+86-0311-81668016，E-mail：zhangds2011@126.com
About author:董晓华，女，副教授，博士；研究方向：神经药理学；Tel：+86-0313-4029305，E-mail：hbdxh76@163.com
Supported by:
河北省科技厅资助项目（No.13272704D），河北省卫生厅资助项目（No.20090183），河北北方学院自然基金项目（No.2009033），河北省张家口市科技局项目（No.0921098D）

摘要/Abstract

摘要： 中枢突触是神经系统中细胞间信息传递和加工的基础环节，中枢突触传递的长时程增强（long-term
potentiation，LTP）现象是研究突触可塑性的有效模型，也是研究学习记忆神经机制的重要指标。LTP的诱导和维持机制十分复杂，很多中枢递质及受体都影响LTP的产生，本文将影响LTP产生的相关中枢受体做一综述，预期对本领域的研究提供一定的参考价值。

关键词: 突触, 长时程增强, 中枢受体, 学习记忆

Abstract: Central Synapse is basic link of information transmission and processing between cells in nervous system，and long-term potentiation of central synapse is an effective model in studying synaptic plasticity and an important marker in investigating the neural mechanisms of learning and memory. The mechanisms inducting and maintaining LTP are very complicated, and many central neurotransmitters and eceptors can affect the production of LTP. In this review, relevant receptor systems affecting LTP production were described and summarized.

Key words: synapse, long-term potentiation, central receptor, learning and memory

董晓华, 孟宪勇, 张丹参. 长时程增强现象与中枢受体[J]. 神经药理学报, 2012, 2(5): 45-50.

DONG Xiao-hua1, MENG Xian-yong2, ZHANG Dan-shen3. Long-term Potentiation and Central Receptors[J]. Acta Neuropharmacologica, 2012, 2(5): 45-50.

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