沉默突触的激活机制及其功能意义

神经药理学报 ›› 2012, Vol. 2 ›› Issue (5): 51-56.

沉默突触的激活机制及其功能意义

蔡靓¹，苏朝芬¹，罗焕敏^1,2

1. 暨南大学医学院药理学系，广州，510632，中国 2. 暨南大学脑科学研究所，广州，510632，中国

出版日期:2012-10-26 发布日期:2014-06-27
通讯作者: 罗焕敏，男，教授，博士生导师；研究方向：神经药理学；Tel/Fax: +86-020-85228869, E-mail: tlhm@jnu.edu.cn
作者简介:蔡靓，女，硕士研究生；研究方向：神经药理学；E-mail：cai2011study@163.com
基金资助:
国家自然科学基金(No.81173037)，国家重点基础研究发展计划（973 计划）（No.2011CB707500），广东省科技计划项目(No.2012B050300018)

Silent Synapses: A Review

CAI Liang¹, SU Chao-fen¹, LUO Huan-min^1,2

1. Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China
2. Institute of Brain Sciences, Jinan University, Guangzhou, 510632, China

Online:2012-10-26 Published:2014-06-27
Contact: 罗焕敏，男，教授，博士生导师；研究方向：神经药理学；Tel/Fax: +86-020-85228869, E-mail: tlhm@jnu.edu.cn
About author:蔡靓，女，硕士研究生；研究方向：神经药理学；E-mail：cai2011study@163.com
Supported by:
国家自然科学基金(No.81173037)，国家重点基础研究发展计划（973 计划）（No.2011CB707500），广东省科技计划项目(No.2012B050300018)

摘要/Abstract

摘要： 沉默突触（silent synapse）是指具有突触结构，但在生理情况下没有传递功能的突触。沉默突触在某些情况下能转变为功能性突触并能增加突触联系（即能与其他末梢形成新的突触）。突触功能与结构上的变化统称为突触的可塑性，它的这一性质与神经修复、记忆改善等过程密切相关。所以，研究沉默突触的形成、功能、激活机制等，意义重大。

关键词: 沉默突触, 谷氨酸, LTP, 神经可塑性, NMDA受体, AMPA受体

Abstract: Silent synapse is defined as a synapse that is incapable of exerting neurotransmission in physiological
conditions but could be activated under certain conditions. The change of function and structure of synapses are defined as plasticity of synapse, and this property of synapses is related to restoration of the neurons and memory improvement. It is essential to understand the mechanisms of formation, function and activation of silent synapse.

Key words: silent synapse, glutamic acid, long-term potentiation, neuronal plasticity, NMDA, AMPA

蔡靓, 苏朝芬, 罗焕敏. 沉默突触的激活机制及其功能意义 [J]. 神经药理学报, 2012, 2(5): 51-56.

CAI Liang , SU Chao-fen , LUO Huan-min, . Silent Synapses: A Review[J]. ACTA NEUROPHARMACOLOGICA, 2012, 2(5): 51-56.

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