神经药理学报

神经药理学报 ›› 2024, Vol. 14 ›› Issue (1): 57-.DOI: 10.3969/j.issn.2095-1396.2024.01.010

• 综述 • 上一篇    

线粒体动力学调控肿瘤相关机制的研究进展

宁康浩，闫聚瀚，闫晓冬，李佳程，李向东   

  1. 1. 河北北方学院研究生学院，张家口，075000，中国 

    2. 河北北方学院附属第一医院泌尿外科，张家口，075000，中国

  • 出版日期:2024-02-26 发布日期:2024-05-24
  • 通讯作者: 李向东，主任医师，教授，硕士研究生导师
  • 作者简介:宁康浩，硕士研究生； E-mail：603467383@qq.com

Advances in the Regulation of Mitochondrial Dynamics on Tumor Cells

NING Kang-hao, YAN Ju-han, YAN Xiao-dong, LI Jia-cheng, LI Xiang-dong   

  1. 1. The Graduate School of Hebei North University, Zhangjiakou, 075000, China 

    2. Department of Urology, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

  • Online:2024-02-26 Published:2024-05-24

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摘要：

线粒体动力学是在生理或刺激状态下，线粒体持续不断的进行分裂和融合，从而调节线粒体在细胞内 的分布、数量、大小以及形状的动态平衡过程。在细胞中，线粒体动力学调控与线粒体的功能密切相关，而线粒体 的功能包括提供能量、调节钙离子稳态，参与细胞程序性死亡、细胞信号转导、细胞代谢等。在肿瘤中，线粒体动 力学调控与肿瘤细胞的增殖、迁移、治疗和耐药等密切相关，因此，线粒体动力学调控成为了肿瘤领域的研究热 点，并在肿瘤治疗中显现出巨大潜力。该篇综述中，我们回顾了介导线粒体动力学调控的关键特征，并讨论了线 粒体动力学调控肿瘤发生发展的相关机制和其在肿瘤治疗方面的可能。

关键词: 线粒体动力学, 线粒体融合, 线粒体分裂, 肿瘤

Abstract:

Mitochondrial dynamics is the dynamic balance process in which mitochondria continuously divide and fuse under physiological or stimulating conditions, thereby regulating the distribution, quantity, size and shape of mitochondria in the cell. In cells, the regulation of mitochondrial dynamics is closely related to the functions of mitochondria, which include providing energy, regulating calcium homeostasis, participating in programmed cell death, cell signal transduction, and cell metabolism. In cancer, mitochondrial dynamic regulation is closely related to the proliferation, migration, treatment and drug resistance of tumor cells. Therefore, mitochondrial dynamic regulation has become a research hotspot in the field of cancer, and has shown great potential in tumor therapy. In this review, we review the key features that mediate mitochondrial dynamic regulation, and discuss the mechanisms involved in tumorigenesis and development and its potential in tumor therapy.

Key words: mitochondrial dynamics, mitochondrial fusion, mitochondria division, tumor