Objective：To observe the acute radiation reaction and therapeutic effect of Biyan jiedu granule on Nasopharyngeal carcinoma （NPC）. Methods：From October 2017 to December 2021，120 patients with nasopharyngeal carcinoma without distant metastasis were randomly divided into two groups. Stratified therapy is performed according to staging and NCCN guidelines. The control group did not take Biyan jiedu granule granule orally during radiotherapy， and the study group took nasopharyngeal Biyan jiedu granule orally during radiotherapy，and the specific dose is 20 g tid. The acute radiation reaction was observed and the clinical effects were compared. Results：There was significant difference in acute radiation oral mucositis and dry mouth between the two groups （P<0.05）. There was no significant difference in 1 - ，2 - and 3 - year local control rate，no distant metastasis rate and overall survival rate （P>0.05）. Conclusion： Oral administration of Biyan jiedu granule during radiotherapy for newly treated patients with nasopharyngeal carcinoma can reduce the symptoms of acute radiation oral mucositis and dry mouth. It is helpful to reduce the radiation damage of normal tissue around nasopharynx，but it does not significantly improve the clinical effect.