神经药理学报

神经药理学报 ›› 2026, Vol. 16 ›› Issue (1): 34-.DOI: 10.3969/j.issn.2095-1396.2026.01.006

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人参皂苷CK 药物递送系统研究进展

吕俊晓，冀帅延，闻波伟，赵丽艳   

  1. 河北北方学院药学院，河北省神经药理学重点实验室，张家口，075000，中国
  • 出版日期:2026-03-02 发布日期:2026-05-07
  • 作者简介:吕俊晓，硕士在读；研究方向：新型给药系统的开发和应用
  • 基金资助:
    河北省属高校基本科研业务计划项目（No. JYT2025007 和JYT2020002），大学生创新训练计划项目（No.S202210092005），河 北北方学院校级项目（No.BSJJ202211），青年研究生导师资助项目（No.DSZZ202510）

Research Advances in Drug Delivery Systems of Ginsenoside CK

LV Jun-xiao, JI Shuai-yan, WEN Bo-wei, ZHAO Li-yan   

  1. Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China
  • Online:2026-03-02 Published:2026-05-07

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摘要：

人参皂苷CK（ginsenoside compound K，CK）虽具药理潜力，但需通过制剂技术转化为实用剂型以提升 疗效、降低毒副作用，促进其从活性成分向临床应用转化。随着药剂学发展，新剂型推动CK 制剂研究不断深入。 该文按照递送系统进行分类，系统综述了CK 在被动靶向、主动靶向、理化性质响应型及非靶向递送系统中的研 究现状，剖析了当前研究存在的问题，为CK 制剂的开发与临床应用提供了新思路和参考依据。

关键词: 人参皂苷CK, 靶向制剂, 偶联物, 研究进展, 药物递送系统

Abstract:

Although ginsenoside CK (CK) has pharmacological potential, it needs to be transformed into practical dosage forms via pharmaceutical formulation technology to improve efficacy, reduce toxic and side effects, and promote its translation from active ingredient to clinical application. With the development of pharmaceutics, novel dosage forms have driven further advances in the research of CK formulations. This paper systematically reviews the research status of CK in passive targeting, active targeting, physicochemical property-responsive and non-targeted delivery systems by classifying according to delivery systems, analyzes the existing problems in current research, and provides new ideas and references for the development and clinical application of CK formulations.

Key words: ginsenoside CK, targeted delivery systems, conjugate, review, drug delivery system

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