神经药理学报

神经药理学报 ›› 2026, Vol. 16 ›› Issue (1): 51-.DOI: 10.3969/j.issn.2095-1396.2026.01.007

• 综述 • 上一篇    下一篇

骨陷窝- 小管网络重塑与骨质疏松—从组织液流动到骨力学生物学的微解剖进展

杨天乐   

  1. 肇庆医学院基础医学院，肇庆，526000，中国
  • 出版日期:2026-03-02 发布日期:2026-05-07
  • 作者简介:杨天乐，硕士研究生，助教
  • 基金资助:
    肇庆医学高等专科学校2024 年校级课程建设示范项目(No.2024-ks5)

Osteocyte Lacunar-Canalicular Network Remodeling and Osteoporosis—Microanatomical Advances from Interstitial Fluid Flow to Bone Mechanobiology

YANG Tian-le   

  1. School of Basic Medicine, Zhaoqing Medical College, Zhaoqing, 526000, China
  • Online:2026-03-02 Published:2026-05-07

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摘要：

骨质疏松症（osteoporosis，OP）以骨量减少和骨微结构破坏为特征，但部分患者骨密度正常却仍发生脆 性骨折，提示单一骨密度不足以评估抗折能力。骨强度由骨量、微结构、基质属性及骨细胞功能等“骨质量”共同 决定。骨陷窝- 小管网络（lacunar-canalicular network，LCN）可将机械负荷转化为组织液流动信号，协调骨形成 与吸收。LCN 随增龄退化、连通性下降与骨脆性相关；其受损时即使骨量正常也会削弱修复与适应。该文综述 LCN 在OP 异质性中的机制，为识别与靶向干预提供参考。

关键词: 骨质疏松症, 骨细胞, 骨陷窝- 小管网络（LCN）, 力学生物转导

Abstract:

Osteoporosis features reduced bone mass and damaged microarchitecture, yet some individuals sustain fragility fractures despite normal bone mineral density (BMD), showing that BMD alone cannot capture fracture resistance. Bone strength is governed by bone quality, integrating mass, microarchitecture, matrix material properties, and osteocyte activity. The osteocyte lacunar–canalicular network (LCN) is the central microanatomical pathway for mechanotransduction and metabolic exchange: it converts mechanical loading into interstitial fluid–flow–mediated cues and propagates signals that tune bone formation and resorption. Studies indicate that aging and disease can reduce LCN connectivity and disturb its geometry, leading to inefficient transport and blunted cellular responses; consequently, microdamage repair and mechanical adaptation decline even when bone mass appears preserved. This review summarizes LCN-centered, multi-physics mechanisms underlying osteoporosis heterogeneity and highlights opportunities for improved risk stratification and targeted interventions.

Key words: osteoporosis, osteocyte, lacunar–canalicular network, mechanotransduction

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