神经药理学报

神经药理学报 ›› 2023, Vol. 13 ›› Issue (3): 49-.DOI: 10.3969/j.issn.2095-1396.2023.03.008

• 研究论文 • 上一篇    下一篇

银杏叶胶囊与盐酸氟桂利嗪联用对偏头痛患者颅内动脉血流动力学及血清β-EP、5-HT、CGRP水平的影响研究

曾俊晟，王特   

  1. 南华大学附属长沙中心医院神经内科，长沙，410028，中国
  • 出版日期:2023-06-26 发布日期:2024-05-09
  • 通讯作者: 王特，硕士，神经内科，副主任医师；E-mail：wangteson@163.com
  • 作者简介:曾俊晟，博士，神经内科，医师；E-mail：Zeng_junsheng8@163.com

Effects of Ginkgo Biloba Capsule Combined with Flunarizine Hydrochloride on Intracranial Arterial Hemodynamics and Serum β-EP, 5-HT and CGRP Levels in Patients with Migraine

ZENG Jun-sheng, WANG Te   

  1. Department of Neurology, Changsha Central Hospital, Changsha, 410028, China
  • Online:2023-06-26 Published:2024-05-09
  • Contact: 王特，硕士，神经内科，副主任医师；E-mail：wangteson@163.com
  • About author:曾俊晟，博士，神经内科，医师；E-mail：Zeng_junsheng8@163.com

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摘要：

目的：研究银杏叶胶囊与盐酸氟桂利嗪联用对偏头痛患者颅内动脉血流动力学及血清β-内啡肽（β-endorphin, β-EP）、5-羟色胺（5-hydroxytryptamine, 5-HT）、降钙素基因相关肽（calcitonin gene-related peptide, CGRP）水平的影响。方法：选取南华大学附属长沙中心医院从2021年1月～2022年12月收治的100例门诊+住院偏头痛患者作为研究对象。以电脑编号随机法分为银杏叶组（n=50）及参考组（n=50）。参考组予以盐酸氟桂利嗪治疗，银杏叶组则于参考组的基础上增用银杏叶胶囊治疗。对比两组疗效，临床症状，颅内动脉血流动力学，血清β-EP、5-HT、CGRP水平。结果：银杏叶组治疗总有效率高于参考组（94.00% vs 78.00%）（P＜0.05）。治疗3个月后两组头痛发作次数、持续时间及头痛强度评分均少于治疗前，且银杏叶组少于参考组（均P＜0.05）。治疗3个月后两组各项颅内动脉血流动力学指标水平均低于治疗前，且银杏叶组低于参考组（均P＜0.05）。治疗3个月后两组血清β-EP、5-HT、CGRP水平较治疗前均改善，且银杏叶组改善程度优于参考组（均P＜0.05）。结论：银杏叶胶囊与盐酸氟桂利嗪联用治疗偏头痛患者的疗效较佳，可改善颅内动脉血流动力学及血清β-EP、5-HT、CGRP水平，值得推广应用。

关键词: 偏头痛, 银杏叶胶囊, 盐酸氟桂利嗪, 颅内动脉血流动力学, β-内啡肽, 5-羟色胺, 降钙素基因相关肽

Abstract:

Objective: To study the effects of Ginkgo biloba capsule combined with flunarizine hydrochloride on intracranial arterial hemodynamics and serum levels of β-endorphin (β-EP), 5-hydroxytryptamine (5-HT) and calcitonin gene-related peptide (CGRP) in patients with migraine. Methods: 100 migraine patients admitted to the hospital from January 2021 to December 2022 were selected as the study objects. Ginkgo biloba group (n=50) and reference group (n=50) were randomly divided by computer numbering method. Reference group was treated with flunarizine hydrochloride, and ginkgo biloba capsule was added to the reference group. The efficacy, clinical symptoms, intracranial arterial hemodynamics, serum β-EP, 5-HT and CGRP levels were compared between the two groups. Results: The total effective rate of ginkgo biloba group was higher than that of reference group (94.00% vs 78.00%) (P < 0.05). After 3 months of treatment, headache frequency, duration and headache intensity scores in both groups were lower than before treatment, and those in ginkgo biloba group were lower than those in reference group (all P < 0.05). After 3 months of treatment, the levels of intracranial arterial hemodynamics indexes in both groups were lower than before treatment, and those in ginkgo biloba group were lower than those in reference group (all P < 0.05). After 3 months of treatment, the levels of serum β-EP, 5-HT and CGRP in both groups were improved compared with those before treatment, and the improvement degree in ginkgo biloba group was better than that in reference group (all P < 0.05). Conclusion: Ginkgo leaf capsule combined with flunarizine hydrochloride has a good effect in the treatment of migraine patients, and can improve intracranial arterial hemodynamics and serum β-EP, 5-HT, CGRP levels, which is worthy of promotion and application.

Key words: migraine, ginkgo biloba capsule, flunarizine hydrochloride, intracranial arterial hemodynamics, beta-endorphins, serotonin, calcitonin gene-related peptide