神经药理学报

神经药理学报 ›› 2021, Vol. 11 ›› Issue (5): 34-.DOI: 10.3969/j.issn.2095-1396.2021.05.006

• 专题论著 • 上一篇    下一篇

心脏右向左分流与偏头痛患者脑白质病变相关性研究进展

李艳晓，薛茜   

  1. 1. 河北北方学院，张家口，075000，中国  2. 河北北方学院附属第一医院神经内科，张家口，075000，中国
  • 出版日期:2021-10-26 发布日期:2021-10-26
  • 通讯作者: 薛茜，主任医师，教授，硕士研究生导师；研究方向：脑血管病、神经重症；E-mail：xueqian6166@163.com
  • 作者简介:李艳晓，硕士研究生；E-mail：1573562917@qq.com

Research Progress on the Relationship between Right to Left Cardiac Shunt and White Matter Lesions in Migraine Patients

LI Yan-xiao，XUE Qian   

  1. 1. Hebei North University ，Zhangjiakou，075000，China  2. The Department of Neurology，The First Affiliated Hospital of Hebei North University，Zhangjiakou，075000， China
  • Online:2021-10-26 Published:2021-10-26

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摘要：

偏头痛（migraine）是一种反复发作的慢性神经血管性头痛，是临床常见的原发性头痛之一，在很大程度上影响患者日常生活和工作，阻碍社会生产力发展并给个人和社会带来了巨大的经济负担。目前大量研究结果提示偏头痛与心脏右向左分流（right-to-left shunt，RLS）存在相关性，但具体原理仍在研究中。有研究表明偏头痛患者脑白质病变（white matter lesions，WML）发生率高于正常人群3 倍，其病理生理学机制尚未阐明。而近年来研究结果提示，偏头痛尤其是先兆性偏头痛（migraine with aura，MA）患者卵圆孔未闭（patent foramen ovale，PFO）患病率较正常人群明显升高。然而偏头痛患者WML 与RLS 之间是否存在相关性，以及二者之间的病理生理机制尚未阐明，有待进一步研究。

关键词: 偏头痛, 右向左分流, 卵圆孔未闭, 脑白质病变

Abstract:

Migraine is a recurrent chronic neurovascular headache. It is one of the common primary headache in clinic. It affects patients’ daily life and work to a great extent，hinders the development of social productivity and brings huge economic burden to individuals and society. At present，a large number of studies at home and abroad have found that migraine is related to right-to-left shunt （RLS），but the specific principle is still under study. Studies have shown that the incidence of white matter lesions （WML） in migraine patients is three times higher than that in normal people，and its pathophysiological mechanism has not been clarified. The results of recent studies suggest that the prevalence of patent foramen ovale （PFO） in migraine patients was significantly higher than that in normal people，especially migraine with aura （MA）. Whether there is a relationship between white matter lesions and right to left shunt in migraine patients， and the pathophysiological mechanisms between them are not clear，which is worthy of further study.

Key words: migraine, right-to-left shunt, patent foramen ovale, white matter lesions

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