神经药理学报 ›› 2020, Vol. 10 ›› Issue (2): 39-45.DOI: 10.3969/j.issn.2095-1396.2020.02.008

• 综述 • 上一篇    下一篇

右美托咪定对术后认知功能障碍影响的研究进展

刘璇,滕金亮   

  1. 河北北方学院附属第一医院,张家口,075000,中国
  • 出版日期:2020-04-26 发布日期:2020-04-26
  • 通讯作者: 滕金亮,主任医师,研究生导师;E-mail:tengjinliang@126.com
  • 作者简介:刘璇,硕士研究生;E-mail:13932380883@163.com

The Research of Dexmedetomidine on Postoperative Cognitive Dysfunction

LIU Xuan,TENG Jin-liang   

  1. The First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China
  • Online:2020-04-26 Published:2020-04-26
  • Contact: 滕金亮,主任医师,研究生导师;E-mail:tengjinliang@126.com
  • About author:刘璇,硕士研究生;E-mail:13932380883@163.com

摘要:

右美托咪定作为一种α2 肾上腺素受体激动药,有高度选择性,药理作用包括抑制交感神经、镇静、催眠、抗焦虑等作用,而且能够保护中枢神经,预防或减少术后认知功能障碍的发生。有研究认为,术中使用右美托咪定能够降低患者的应激反应,降低炎性因子的释放,进一步改善患者术后认知功能。该文就右美托咪定对术后认知功能障碍影响的研究进展进行阐述。

关键词: 右美托咪定, 炎性因子, 术后认知功能障碍

Abstract:

Dexmedetomidine,as a highly selective α2-adrenergic receptor agonist. Its pharmacological effects include sympathetic inhibition,sedation,hypnosis,anti-anxiety. It can also protect central nervous system and reduce the incidence of postoperative cognitive dysfunction. Some studies believe that dexmedetomidine can reduce the stress response,inhibit the inflammatory response,reduce the release of inflammatory factors and improve the postoperative cognitive function of patients. In this paper,the effect of dexmedetomidine on postoperative cognitive dysfunction will be discussed.

Key words: dexmedetomidine, inflammatory factors, postoperative cognitive dysfunction