神经干细胞对胶质瘤发生发展影响的研究进展

摘要/Abstract

摘要： 神经干细胞具有自我更新、不断增殖及多向分化的特性，以至在胶质瘤的发生和发展中产生重要的影响。胶质瘤的发生和发展是一个多步骤的复杂过程，涉及大量相关基因、转录因子、信号通路及其它们的相关蛋白，还有一些生长因子和酶等表达和调控的改变。

关键词: 神经干细胞, 胶质瘤干细胞, 胶质瘤, 起源, 胶质瘤发生, 发病机制

Abstract: Neural stem cells have the properties of self-renewal，continuous proliferation and multidifferentiation，which play an important role in the occurrence and development of glioma. The occurrence and development of glioma is a complex multi-step process，involving the changes of a number of related genes，transcription factors，signaling pathways and their associated proteins，as well as some growth factors and enzymes in expression and regulation.

Key words: neural stem cells, glioma stem cells, glioma, origin, gliomagenesis, pathogenesis

罗林明, 姜懿纳, 陈乃宏. 神经干细胞对胶质瘤发生发展影响的研究进展[J]. 神经药理学报, 2015, 5(5): 28-33.

LUO Lin-ming, JI Yi-na, CHEN Nai-hong. Research Progress on the Effect of Neural Stem Cells in the Occurrence and Development of Glioma[J]. ACTA NEUROPHARMACOLOGICA, 2015, 5(5): 28-33.

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