糖尿病与阿尔茨海默病的相关性研究进展

摘要/Abstract

摘要： 近年来，阿尔兹海默病（Alzheimer’s disease，AD）的患病人数逐年增多，但由于其发病机制尚不明确，对于该病目前无十分有效的治疗方法。流行病学调查研究发现AD的发生与糖尿病存在紧密的联系，并有证据表明一些抗糖尿病药物对AD有效，这为AD的治疗提供了新策略。本文综述了糖尿病与AD的相关性、糖尿病诱发AD的机制研究以及糖尿病治疗药物胰高血糖素样肽1（glucagon-like peptide 1，GLP-1）类似物对AD的作用研究。

关键词: 阿尔兹海默病, 糖尿病, 胰高血糖素样肽1, GLP-1R

Abstract: The incidence of Alzheimer’s disease (AD) is largely increased in the recent years. However, no available therapeutic regimens are successful treatment on the symptoms or altering the disease course of AD due to its undisclosed molecular mechanisms. Epidemiological data shows that diabetes mellitus is closely associated with AD incidence. Meanwhile, some antidiabetic drugs were found effectively to prevent or alleviate the symptom of AD, which may provide a new therapeutic strategy for future AD treatment. This article reviews the correlation between diabetes and AD, the mechanism about how diabetes causes AD, and the research progress of glucagon-like peptide 1 (GLP-1) analogues on AD treatment.

Key words: Alzheimer&, rsquo, s disease, diabetes mellitus, glucagon-like peptide 1, GLP-1R

裴双超，艾静. 糖尿病与阿尔茨海默病的相关性研究进展[J]. 神经药理学报, 2015, 5(4): 55-64.

PEI Shuang-chao, AI Jing. Research Progress on the Correlation Between Diabetes and Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2015, 5(4): 55-64.

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