神经药理学报 ›› 2014, Vol. 4 ›› Issue (4): 50-58.

• 综述 • 上一篇    下一篇

急性脑缺血治疗药物研究进展

张雯,宋俊科,杜立达,张雪,杜冠华   

  1. 中国医学科学院&北京协和医学院药物研究所,北京市药物靶点研究与新药筛选重点实验室,北京 100050
  • 出版日期:2014-08-26 发布日期:2015-01-20
  • 通讯作者: 杜冠华,男,博士生导师; Tel:+86-010-63165184, E-mail: dugh@imm.ac.cn
  • 作者简介:张雯,女,博士研究生;E-mail: zhangwen9010@imm.ac.cn
  • 基金资助:

    国家“重大新药创制”科技重大专项(No. 2012ZX09103-101-078);国家“重大新药创制”科技重大专项(No. 2013ZX09102106)

Advances in Pharmacologic Treatment of Acute Cerebral Ischemia

ZHANG Wen,SONG Jun-ke,DU li-da,ZHANG Xue,DU Guan-hua   

  1. Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050,China
  • Online:2014-08-26 Published:2015-01-20
  • Contact: 杜冠华,男,博士生导师; Tel:+86-010-63165184, E-mail: dugh@imm.ac.cn
  • About author:张雯,女,博士研究生;E-mail: zhangwen9010@imm.ac.cn
  • Supported by:

    国家“重大新药创制”科技重大专项(No. 2012ZX09103-101-078);国家“重大新药创制”科技重大专项(No. 2013ZX09102106)

摘要: 急性脑缺血是目前严重威胁人类健康的重大疾病,其病理生理机制复杂,至今尚无有效理想的治疗药物。寻找有效的治疗药物是目前研究的热点。本文总结了目前临床治疗应用的药物,回顾了近年来国内外抗急性脑缺血药物研究的相关文献,总结了各类脑缺血治疗药物的近况。

关键词: 脑缺血, 神经保护, 溶栓, 血管扩张

Abstract: Acute cerebral ischemia is one of the most threating diseases to human health, with extremely complex pathophysiological mechansm. Given that there are almost no ideal therapeutic drugs in clinical, current research has focused on finding new effective pharmacological treatment. Systematically reviewing a number of acute cerebral ischemia literatures at home and abroad, this paper summarized the research situation of various types of anti-cerebral ischemia drugs, with emphasis on the clinical medication in this field.

Key words: Cerebral ischemia, neuroprotection, thrombolysis, vasodilator.

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