神经药理学报 ›› 2014, Vol. 4 ›› Issue (1): 1-10.

• 研究回顾 •    下一篇

丹酚酸B神经保护作用的机制与研究进展

唐民科1 ,范悦1 ,刘长锁2 ,张均田2   

  1. 1. 北京中医药大学,北京 100102
    2. 中国医学科学院,中国协和医科大学药物研究所,北京 100005
  • 出版日期:2014-02-26 发布日期:2014-06-06

Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B

Tang Min-ke1,Fan Yue1,Liu Chang-suo2,Zhang Jun-tian2   

  1. 1Beijing university of Chinese Medicine, Beijing, 100102, China. 2Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China
  • Online:2014-02-26 Published:2014-06-06

摘要: 本文综述了丹酚酸B(Sal B)对β-淀粉样蛋白(Aβ)、tau蛋白毒性及两者引起的PC12细胞和SH-SY5Y细胞凋亡的作用,对神经发生、血管生成的影响。结果发现Sal B能抑制Aβ的原纤维成形、聚集,降低毒性并减少其引起的细胞凋亡;抑制tau蛋白的过度磷酸化;促进神经发生和血管生成。基于Sal B对神经系统的保护作用,故其可能作为治疗神经退行性疾病的潜在药物。

关键词: 丹酚酸B, &, beta, -淀粉样蛋白, Tau蛋白, 神经发生, 血管生成

Abstract: This paper reviewed the effect of Salvianolic acid-B (Sal B) on toxicity of amyloid β-protein (Aβ), tau protein and PC12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein, and on neurogenesis and angiogenesis.The results showed that Sal B could decrease the toxicity of Aβ by inhibiting Aβ aggregation and fibril formation, and protect cells damaged by Aβ.Hyperphosphoylation of tau protein could be attenuated by Sal B.Sal B has also been proved to promote neurogenesis and angiogenesis.Based on the neuroprotective effect of Sal B, it may be a potential medicine for treatment of neurodegenerative disease.

Key words: Salvianolic acid-B, amyloid-&, beta, tau protein, neurogenesis, angiogenesis