丹酚酸B神经保护作用的机制与研究进展

摘要/Abstract

摘要： 本文综述了丹酚酸B（Sal B）对β-淀粉样蛋白（Aβ）、tau蛋白毒性及两者引起的PC12细胞和SH-SY5Y细胞凋亡的作用，对神经发生、血管生成的影响。结果发现Sal B能抑制Aβ的原纤维成形、聚集，降低毒性并减少其引起的细胞凋亡；抑制tau蛋白的过度磷酸化；促进神经发生和血管生成。基于Sal B对神经系统的保护作用，故其可能作为治疗神经退行性疾病的潜在药物。

关键词: 丹酚酸B, &, beta, -淀粉样蛋白, Tau蛋白, 神经发生, 血管生成

Abstract: This paper reviewed the effect of Salvianolic acid-B (Sal B) on toxicity of amyloid β-protein (Aβ), tau protein and PC12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein, and on neurogenesis and angiogenesis．The results showed that Sal B could decrease the toxicity of Aβ by inhibiting Aβ aggregation and fibril formation, and protect cells damaged by Aβ．Hyperphosphoylation of tau protein could be attenuated by Sal B．Sal B has also been proved to promote neurogenesis and angiogenesis．Based on the neuroprotective effect of Sal B, it may be a potential medicine for treatment of neurodegenerative disease.

Key words: Salvianolic acid-B, amyloid-&, beta, tau protein, neurogenesis, angiogenesis

唐民科，范悦，刘长锁，张均田. 丹酚酸B神经保护作用的机制与研究进展[J]. 神经药理学报, 2014, 4(1): 1-10.

Tang Min-ke，Fan Yue，Liu Chang-suo，Zhang Jun-tian. Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B[J]. Acta Neuropharmacologica, 2014, 4(1): 1-10.

参考文献

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