血管性痴呆的中西医治疗进展

神经药理学报 ›› 2014, Vol. 4 ›› Issue (1): 29-33.

血管性痴呆的中西医治疗进展

刘丰熙¹ 牛凯² 薛贵平¹

1. 河北北方学院药学系，张家口，075000，中国
2. 圣大（张家口）药业有限公司，张家口，075000，中国

出版日期:2014-02-26 发布日期:2014-06-06
作者简介:刘丰熙，女，讲师，硕士；研究方向：中医药抗衰老；E-mail：liufengxi1613@163.com

The Therapeutic Progress of Vascular Dementia in Terms of Modern Medicine and Chinese Traditional Treatment

LIU Feng-xi¹, NIU Kai², XUE Gui-ping¹

1. Department of Pharmacy, Hebei North University, Zhangjiakou, 075000, China
2. Santa (Zhangjiakou) Pharmaceutical Co., LTD., Zhangjiakou, 075000, China

Online:2014-02-26 Published:2014-06-06
About author:刘丰熙，女，讲师，硕士；研究方向：中医药抗衰老；E-mail：liufengxi1613@163.com

摘要/Abstract

摘要： 血管性痴呆（vascular dementia，VD）是指因脑血管疾病所致的认知功能障碍综合征，已经成为现代社会导致精神和躯体残疾的重要因素之一。而且，VD是迄今为止唯一可防治的痴呆类型，如早期治疗可使预后明显改善。本文从现代医学和传统医学的角度出发综述了VD的治疗进展。

关键词: 血管性痴呆, 现代医学, 中医治疗

Abstract: Vascular dementia refers to a kind of cognitive dysfunction syndrome induced by cerebrovascular diseases and is one of important factors for mental disturbance and physical disability in modern society. In addition, VD, so far, is only avertable dementia type. If early diagnosis and effective therapy, the prognosis can be improved remarkably. The present paper reviewed the therapeutic progress in terms of modern medicine and Chinese traditional treatment.

Key words: vascular , dementia, modern medicine, Chinese traditional treatment

刘丰熙, 牛凯, 薛贵平. 血管性痴呆的中西医治疗进展[J]. 神经药理学报, 2014, 4(1): 29-33.

LIU Feng-xi, NIU Kai, XUE Gui-ping. The Therapeutic Progress of Vascular Dementia in Terms of Modern Medicine and Chinese Traditional Treatment[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 29-33.

参考文献

[1] Neil M Davies, Patrick G Kehoe, Yoav Ben-Shlomo, et al. Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias[J]. J Alzheimers Dis, 2011, 26(4): 699-708.

[2] D S Yadav. Dementia classification[J]. Advances in Psychiatric Treatment, 2012, 18(4): 315-316.

[3] S E Black. Vascular cognitive impairment: epidemiology, subtypes, diagnosis and management[J]. J R Coll Physicians Edinb, 2011, 41(1): 49-56.

[4] Dietmar Rudolf Thal, Lea Tenenholz Grinberg, Johannes Attems. Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain [J]. Exp Gerontol, 2012, 47(11): 816-824.

[5] Leonardo Pantoni, Teodoro del Ser, Andrea G Soglian, et al. Efficacy and safety of nimodipine in subcortical vascular dementia a randomized placebo-controlled trial [J]. Stroke, 2005, 36(3): 619-624.

[6] 沈树红, 王少石, 朱鑫璞, 等. 钙拮抗剂对血管性痴呆患者认知功能和脑血流及脑微循环的影响[J]. 中国临床康复, 2005, 9(13): 44-45.

[7] 侯德仁, 陈坤, 王艳, 等. 丁苯酞治疗血管性痴呆的疗效和作用机制[J]. 南方医科大学学报, 2009, 29(3): 574-575.

[8] 卢海丽, 杨建芳, 赵新民, 等. 血管性痴呆的治疗现状[J]. 河北医药, 2010, 32(13): 1790-1792.

[9] Darin Jaturapatporn, Mokhtar Gad EI Kareem, Nasr Isaac, et al. Aspirin, steroid and non-steroidal anti-inflammatory drugs use for treating Alzheimer's disease[J]. Cochrane Database Syst Rev, 2012, 2: CD006378.

[10] 王爱华. 高压氧治疗血管性痴呆症的疗效观察[J]. 中国实用医药, 2013, 8(20): 113-114.

[11] 肖雁, 吴昌学, 黄勇, 等. 脑通复方制剂对血管性痴呆大鼠学习记忆及胆碱酯酶活性的影响[J]. 中国医院药学杂志, 2010, 8: 627-630.

[12] Andrius Baskys, Cheng Jin-xiang. Pharmacological prevention and treatment of vascular dementia: Approaches and perspectives[J]. Experimental Gerontology, 2012, 47(11): 887-891.

[13] 杜井波, 翁秋霖, 陈小虎, 等. 石杉碱甲对不同严重程度血管性痴呆患者的疗效分析[J]. 中国临床神经科学, 2011, 19(5): 510-514.

[14] 王伟良, 蒋世峰, 徐伟民, 等. 盐酸多奈哌齐与石杉碱甲治疗血管性痴呆的疗效研究[J]. 河北医学, 2010, 16(10): 1163-1166.

[15] 张晓锋, 陈淅泠, 王欣东. 盐酸美金刚对血管性痴呆大鼠海马 CA1 区 BDNF 及 ERK 表达的影响[J]. 中国实用神经疾病杂志, 2010, 13(4): 19-21.

[16] Jae-Hyun Park, Sang Won Seo, Changsoo Kim, et al. Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment[J]. Neurobiol Aging, 2013, 35(1): 254-60.

[17] Andressa Bernardi, Rudimar L Frozza, Andre Meneghetti, et al. Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer’s disease models[J]. Int J Nanomedicine, 2012, 12(7): 4927-4942.

[18] 李宏建. 长期胞二磷胆碱治疗可改善卒中后血管性认知损害[J]. 国际脑血管病杂志, 2013, 21(4): 298-298.

[19] 何杏梅. 血管性痴呆载脂蛋白E基因多态性检测及其意义[J]. 吉林医学, 2012, 33(12): 2495-2496.

[20] 马宏博, 司国民, 彭敏. 血管性痴呆中医证候分布规律文献分析[J]. 世界中西医结合杂志, 2012, 7(3): 185-186, 221.

[21] 张敏, 张卫珍. 六味地黄汤加味治疗血管性痴呆36例[J]. 陕西中医, 2001, 22(2): 85-85.

[22] 冯炯, 臧敏. 六味地黄丸对痴呆模型小鼠学习记忆及细胞因子的影响[J]. 山东中医杂志, 2010, 29(4): 264-265.

[23] 王震宇. 补阳还五汤治疗血管性痴呆39例[J]. 陕西中医, 2005, 26(8): 781-782.

[24] Lin Zhi-hong, Gu Jie, Xiu Jin, et al. Traditional chinese medicine for senile dementia[J]. Evid Based Complement Alterna Med, 2011, 3(12): 1-13.

[25] 包祖晓, 唐启盛. 陈士铎从心肾不交论治神志病[J]. 吉林中医药, 2007, 27(5): 1-2.

[26] 张海燕, 刘忠锦, 冯化杰, 等. 天王补心丹对AD模型大鼠学习记忆及PKC、Aβ的影响[J]. 中国医学创新, 2012, 9(21): 12-13.

[27] 邱艳华. 天王补心丹治疗脑神经衰弱及记忆力减退病症报告[J]. 现代康复, 1998, 06: 569.

[28] 曹金梅, 刘文刚, 吴淮. 醒脑化痰针法对血管性痴呆大鼠学习记忆及脑组织SOD和MDA的影响[J]. 中医研究, 2009, 22(07): 10-12.

[29] 赵惠, 孔波, 喻巍, 等. 原络配穴为主治疗血管性轻度认知障碍24例[J]. 针灸临床杂志, 2011, 27(05): 36-38.

[30] 王鹏琴, 赵辉, 王丽. 眼针疗法治疗血管性痴呆的临床观察[J]. 辽宁中医杂志, 2003, 30(05): 392-393.

[31] 王惠明. 电针法治疗血管性痴呆临床疗效观察[J]. 天津中医药, 2007, 24(03): 218-220.

[32] 林树芬, 康西忠, 刘丽. 生物全息穴注射神经络素治疗早期血管性痴呆70例[J]. 中西医结合心脑血管病杂志, 2006, 4(03): 267.