神经药理学报 ›› 2013, Vol. 3 ›› Issue (3): 57-64.
• 综述 • 上一篇
张思1, 顾兵1, 李华南2, 张国福2, 张水印1, 闵友江2
出版日期:2013-06-26
发布日期:2014-06-27
通讯作者:
顾兵，男，博士后，教授，硕士生导师；研究方向：神经精神药物学；E-mail: bguemory@hotmail.com
作者简介:张思，女，硕士生；研究方向：化学生物学；E-mail: 847404553 @qq.com
基金资助:国家自然科学基金项目（No.30960448），江西省自然科学基金项目（No.20114BAB205033），江西省教育厅科技项目（No.GJJ11596、No.GJJ12584）
ZHANG Si1, GU Bing1, LI Hua-nan2, ZHANG Guo-fu2, ZHANG Shui-yin1, MIN You-jiang 2
Online:2013-06-26
Published:2014-06-27
Contact:
顾兵，男，博士后，教授，硕士生导师；研究方向：神经精神药物学；E-mail: bguemory@hotmail.com
About author:张思，女，硕士生；研究方向：化学生物学；E-mail: 847404553 @qq.com
Supported by:国家自然科学基金项目（No.30960448），江西省自然科学基金项目（No.20114BAB205033），江西省教育厅科技项目（No.GJJ11596、No.GJJ12584）
摘要： 脊髓损伤（spinal cord injury，SCI）通常是指脊髓（包含神经根）的急性创伤。一旦发生就会造成不同程度的运动及感觉功能的丧失。目前认为传统的干细胞移植尚不能完全修复SCI。诱导多能干细胞（induced pluripotent stem cells，iPSCs）兼具干细胞的多种优点，因而在细胞替代性治疗及其机制研究、新药筛选方面具有巨大的潜在价值。本文通过介绍iPSCs生物学特性及其技术现状、综述iPSCs移植治疗SCI的研究现状以及面临困境，指出应用于临床尚需解决的问题。
中图分类号:
张思, 顾兵, 李华南, 张国福, 张水印, 闵友江. 诱导多能干细胞及其移植治疗脊髓损伤的研究现状[J]. 神经药理学报, 2013, 3(3): 57-64.
ZHANG Si, GU Bing, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin, MIN You-jiang . Induced Pluripotent Stem Cells and Their Transplantation for Spinal Cord Injury: Current Status[J]. Acta Neuropharmacologica, 2013, 3(3): 57-64.
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