行为药理学：历史与现状

摘要/Abstract

摘要： 行为药理学作为药理学的一个分支，其发展历史已有50余年。从1955年Peter Dews发表其代表性论文《Studies on behavior. I》以来，行为药理学从无到有，已经发展成为一个活跃的、生机勃勃的新学科。本文拟回顾行为药理学的发展历程，理清其历史发展的脉络，并就行为药理学当前发展的状况作一综述。本文还将提出行为药理学研究中所应注意的几个问题供讨论。

关键词: 行为药理学, 历史, 现状

Abstract: As a branch of pharmacology，behavioral pharmacology has been stepping into its 50s. Since the publication of the hallmark paper of this field in 1955，behavioral pharmacology has seen a steady，vibrant and healthy development. This review traced back into 1950s，summarizing the major events during the history of behavioral pharmacology，and discuss the current status in this field. The paper also discussed several issues related to behavioral pharmacology research.

Key words: Behavioral pharmacology, history, current status

李俊旭. 行为药理学：历史与现状[J]. 神经药理学报, 2011, 1(1): 55-64.

LI Jun-xu. Behavioral Pharmacology: History and Current Status[J]. Acta Neuropharmacologica, 2011, 1(1): 55-64.

参考文献

1   James Barrett. The emergence of behavioral pharmacology[J]. Mol Interv，2002，2(8):470-475
2  James Barrett. Behavioral determinants of drug action. The contributions of Peter B. Dews[J].J Exp Anal Behav，2006，86(3):359-370
3    Robert Julien. Barbiturates，general anesthetics，GHB and antiepileptic drugs[M]//Julien RM. A primer of drug action. 10^th edition. New York(USA)：Worth Publishers，2005: 140-163
4 Sigmund Exner. Experimentelle Untersuchung der einfachsten psychischen process [M]//Pfluger EFW. Archiv fur die gesammte physiologie des menschen und der thiere. Bonn(Germany)：Verlag von Max Cohen & Sons，1873: 601-660
5   Igor Zavadski. An application of the method of conditioned reflexes to pharmacology. Towards the problem of the effects of certain drugs (alcohol，morphine，cocaine，and caffeine) on the function of the higher regions of the central nervous system[J]. Proceedings of the Russian Medical Society in St. Petersburg，1908，75(2):269-287
6    Burrhus Skinner，Heron WT. Effects of caffeine and benzedrine upon conditioning and extinction[J]. The Psychological Record，1937，1(1):340-346
7     Colin Stewert. Variations in daily activity produced by alcohol and by changes in barometric pressure and diet，with a description of recording methods[J]. Am J Physiol，1898，1(1):40-56
8   Fred D'Amour，Donn Smith. A method for determining loss of pain sensation[J]. J Pharmacol Exp Ther，1941，72(1):74-79
9     Peter Dews. The measurement of the influence of drugs on voluntary activity in mice [J]. Br J Pharmacol，1953，8(1):46-48
10 Burrhus Skinner. Operant behavior[M]//Skinner BF. About behaviorism. New York(USA)： Alfred A. Knopf，1980:46-71
11  William Morse，Roger Kelleher. Schedules using noxious stimuli. I. Multiple fixed-ratio and fixed-interval termination of schedule complexes[J]. J Exp Anal Behav，1966，9(3):267-290
12 Charles Ferster，Burrhus Skinner. Schedules of reinforcement[M]. New York(USA)：Appleton-Century-Crofts，1957: 1-758
13   Jonathan Katz. About P. B. Dews. [J/OL] ASPET, Bethesda, 2002, [2011-04-25]. http://www.aspet.org/BehavioralPharmacologyPage.aspx?id=1048
14 Peter Dews. Studies on behavior I: differential sensitivity to pentobarbital of pecking performance in pigeons depending on the schedule of reward[J]. J Pharmacol Exp Ther，1955，113(4):393-401
15  Irving Geller，Joseph Seifter. The effects of mono-urethans，di-urethans and barbiturates on a punishment discrimination[J]. J Pharmacol Exp Ther，1962，136(3):284-288
16   Jackson Marr. A major trio[J]. J Exp Anal Behav，2006，86(3):355-357
17  Travis Thompson，Charles Schuster. Behavioral pharmacology[M]//New Jersey. 1st Print edition，USA：Prentice Hall，1968
18    Peter Dews. A behavioral effect of amobarbital[J]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol，1964，248(4):296-307
19  Roger Kelleher，William Morse. Escape behavior and punished behavior[J]. Fed Proc，1964，23(2):808-817
20   Roger Kelleher，William Morse. Determinants of the specificity of behavioral effects of drugs[J]. Ergeb Physiol，1968，60(1):1-56
21 James Weeks. Experimental morphine addiction: method for automatic intravenous injections in unrestrained rats[J]. Science，1962，138(3537):143-144
22   Travis Thompson，Charles Schuster. Morphine self administration，food reinforced，and avoidance behaviors in rhesus monkeys[J]. Psychopharmacologia，1964，5(2):87-94
23 James McKearney. Effects of d-amphetamine，morphine and chlorpromazine on responding under fixed-interval schedules of food presentation or electric shock presentation[J]. J Phamacol Exp Ther，1974，190(1):141-153
24 James Barrett. Effects of alcohol，chlordiazepoxide，cocaine and pentobarbital on responding maintained under fixed-interval schedules of food or shock presentation[J]. J Phamacol Exp Ther，1976，196(3):605-615
25    Marc Branch. Rate dependency，behavioral mechanisms，and behavioral pharmacology[J]. J Exp Anal Behav，1984，42(3):511-522
26    李俊旭. 药物辨别技术：理论与应用[J]. 中国药物依赖性杂志，2008，17(4):267-270
27 Victor Laties. Behavior analysis and the growth of behavioral pharmacology[J]. Behav Analyst，2003，26(2):235-252
28 Behavioral Pharmacology Division [DA/OL] ASPET, Bethesda, 2002, [2011-04-25]. http://www.aspet.org/BehavioralPharmacologyPage.aspx?id=1111
29    ACNP [DB/OL] American College of Neuropsychopharmacology, Brentwood, 2010 [2011-04-25] http://www.acnp.org/annualmeeting/programbooks.aspx
30   James Woods. Looking to the future of behavioral pharmacology while being attentive to its past[J]. Exp Clin Psychopharmacol，2000，8(1):147-149
31 Blaine McGuire，Michelle Baladi，Charles France. Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats[J]. ，2011，658(2-3):156-159Eur J Pharmacol
32   Elena Zakharova，Dean Wade，Sara Izenwasser. Sensitivity to cocaine conditioned reward depends on sex and age[J]. ，2009，92(1):131-134Pharmacol Biochem Behav
33  Lisa Gerak，Ruggero Galici，Charles France. Self administration of heroin and cocaine in morphine-dependent and morphine-withdrawn rhesus monkeys[J]. ，2009，204(3):403-411Psychopharmacology (Berl)
34  Gregory Collins，James Witkin，Amy Newman et al. Dopamine agonist-induced yawning in rats: a dopamine D3 receptor-mediated behavior[J]. J Pharmacol Exp Ther，2005，314(1):310-319
35  William Fantegrossi，Simoneau J，Cohen MS，et al. Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2，5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice[J]. ，2010，335(3):728-734J Pharmacol Exp Ther
36 Jun-Xu Li，Wouter Koek，Kenner Rice et al. Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys[J]. Neuropsychopharmacology，2011，36(5):940-949
37 Jun-Xu Li，Kenner Rice，Charles France. Discriminative stimulus effects of 1-(2，5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys[J]. J Pharmacol Exp Ther，2008，324(2):827-833
38   Terry Kenakin，Ongun Onaran. The ligand paradox between affinity and efficacy: can you be there and not make a difference[J]? Trends Pharmacol Sci，2002，23(6):275-280
39   Jerrold Winter，Richard Rabin. Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination [J]. J Pharmacol Exp Ther，1992，263(2):682-689
40 Harish Thiagaraj，Ethan Russo，Andrea Burnett, et al. Binding properties of dipropyltryptamine at the human 5-HT1a receptor[J]. Pharmacology，2005，74(4):193-199
41    Jun-Xu Li，Kenner Rice，Charles France. Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity[J]. Behav Pharmacol，2007，18(4):283-288
42  Eric Ewan，Thomas Martin. Opioid facilitation of rewarding electrical brain stimulation is suppressed in rats with neuropathic pain[J]. Anesthesiology，2011，114(3):624-632
43   Patrick Little，David Compton，Ross Johnson, et al. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice[J]. J Pharmacol Exp Ther，1988，247(3):1046–1051