神经药理学报

神经药理学报 ›› 2022, Vol. 12 ›› Issue (6): 45-50.DOI: 10.3969/j.issn.2095-1396.2022.06.008

• 研究论文 • 上一篇    下一篇

铜绿假单胞菌分泌系统及其毒力因子研究进展

韩美娟，汤建华，刘云宁   

  1. 1. 河北北方学院药学院，河北省神经药理学重点实验室，张家口，075000，中国  2. 河北北方学院附属第一医院药学部，张家口，075000，中国
  • 出版日期:2022-12-26 发布日期:2023-08-30
  • 通讯作者: 汤建华，主任药师，教授，硕士生导师；研究方向：抗菌药物耐药机制
  • 作者简介:韩美娟，硕士在读；研究方向：抗菌药物耐药机制；E - mail：1253905771@qq.com

Research Progress on the Secretion System and Virulence Factors of Pseudomonas Aeruginosa

HAN Mei - juan，TANG Jian - hua，LIU Yun - ning   

  1. 1. Department of Pharmacy，Hebei North University，Hebei Key Laboratory of Neuropharmacology，Zhangjiakou， 075000，China 2. Department of Pharmacy，The First Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China
  • Online:2022-12-26 Published:2023-08-30

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摘要：

铜绿假单胞菌（pseudomonas aeruginosa，PA）是临床常见的革兰阴性杆菌，对多种抗菌药物表现出固有 或获得性耐药。PA 通过分泌系统及其毒力因子促进感染或逃脱宿主免疫系统的清除，是其重要的致病机制。研 究PA 分泌系统毒力因子的致病机制对预防和治疗其引起的感染具有重要意义。

关键词: 铜绿假单胞菌, 分泌系统, 毒力因子

Abstract:

Pseudomonas aeruginosa，a common gram - negative bacterium in clinical practice，showed inherent or acquired resistance to a variety of antimicrobial agents. Pseudomonas aeruginosa is an important pathogenic mechanism of the secretory system and its virulence factors to promote infection or escape the clearance of the host immune system. It is of great significance to study the pathogenesis of virulence factors in Pseudomonas aeruginosa secretion system for prevention and treatment of infection caused by them.

Key words: pseudomonas aeruginosa, secretory system, virulence factor