神经药理学报

神经药理学报 ›› 2020, Vol. 10 ›› Issue (6): 27-33.DOI: 10.3969/j.issn.2095-1396.2020.06.005

• 实验方法学 • 上一篇    下一篇

耐碳青霉烯类肺炎克雷伯杆菌耐药机制的研究进展

詹旭莉，汤建华   

  1. 河北北方学院附属第一医院药学部，张家口，075000，中国
  • 出版日期:2020-12-26 发布日期:2020-12-26
  • 作者简介:詹旭莉，女，硕士研究生在读；研究方向：临床药学

Research Progress in Mechanism of Drug Resistance of Carbapenem-Resistant Klebsiella Pneumoniae

ZHAN Xu-li，TANG Jian-hua   

  1. Department of Pharmacy，the First Affiliated Hospital of Hebei North University，Zhangjiakou，075000，China
  • Online:2020-12-26 Published:2020-12-26
  • About author:詹旭莉，女，硕士研究生在读；研究方向：临床药学

PDF (PC)

62

摘要：

耐碳青霉烯类肺炎克雷伯杆菌(Carbapenem-resistant Klebsiella pneumoniae，CRKP)是临床分离及医 院感染的重要致病菌之一，随着β- 内酰胺类及氨基糖苷类等广谱抗菌素的广泛使用，细菌易产生超广谱β- 内 酰胺酶、头孢菌素酶和氨基糖苷类修饰酶，对常用药物包括第三代头孢菌素和氨基糖苷类呈现出严重的多重耐 药性。由于 CRKP 对大部分抗生素均耐药，目前已成为临床治疗非常棘手的问题。加强细菌耐药监测、减少抗 生素滥用导致的细菌耐药已变的十分重要。因此有必要对 CRKP 进行系统性梳理，讨论其耐药机制，为今后临 床合理选择抗菌药物，优化医疗资源提供参考依据。


关键词: 耐碳青霉烯类肺炎克雷伯杆菌, 产碳青霉烯酶, 外膜孔蛋白, 外排泵, 生物被膜

Abstract:

Carbapenem-resistant Klebsiella pneumoniae(Carbapenem-resistant Klebsiella pneumoniae，CRKP)is one of the important pathogenic bacteria isolated clinically and nosocomial infections. As the beta lactam class and aminoglycoside the wide use of broad-spectrum antibiotics， bacteria easy generation ultra broad spectrum beta lactamase，cephalosporins，enzyme and aminoglycoside modifying enzyme，to commonly used medicines including third-generation cephalosporin and aminoglycoside presents severe multiple drug resistance. Because CRKP is resistant to most antibiotics，it has become a very difficult problem in clinical treatment. It has become important to strengthen the monitoring of bacterial resistance and reduce bacterial resistance caused by overuse of antibiotics. Therefore，it is necessary to systematically sort out CRKP and discuss its drug resistance mechanism，so as to provide reference basis for rational selection of antibacterial drugs and optimization of medical resources in the future.


Key words: Carbapenem-resistant Klebsiella pneumoniae, carbapenemase-producing, outer membrane porin, efflux pump, biofilm

中图分类号: