神经药理学报

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自噬与骨形成蛋白在疾病中的关系

郝军荣,张丹参,巩跃文   

  1. 1. 河北北方学院药学系,河北省神经药理学重点实验室,张家口,075000,中国
    2. 河北科技大学,石家庄,050018,中国
    3. 曼尼托巴大学药学院,卫生与科学学院,温尼伯,加拿大
  • 出版日期:2017-12-26 发布日期:2017-12-01
  • 通讯作者: 巩跃文,男,教授;研究方向:肝纤维化、肝衰竭机理的研究;E-mail:yuewen.gong@umanitoba.ca
  • 作者简介:郝军荣,女,讲师;研究方向:神经药理学及相关药物;Tel:+86-0313-4029305,E-mail:haojunrong3@163.com

Autophagy and Bone Mmorphogenetic Proteins in Diseases and Their Relationship

HAO Jun-rong,ZHANG Dan-shen,GONG Yue-wen   

  1. 1. Department of Pharmacy,Hebei North University,Hebei Key Laboratory of Neuropharmacology,Zhangjiakou,075000,China
    2. Hebei University of Science and Technology,Shijiazhuang,050018,China
    3. College of Pharmacy,Faculty of Health Sciences,University of Manitoba,750 McDermot Avenue,Winnipeg,Canada
  • Online:2017-12-26 Published:2017-12-01
  • Contact: 巩跃文,男,教授;研究方向:肝纤维化、肝衰竭机理的研究;E-mail:yuewen.gong@umanitoba.ca
  • About author:郝军荣,女,讲师;研究方向:神经药理学及相关药物;Tel:+86-0313-4029305,E-mail:haojunrong3@163.com

摘要:

自噬在疾病中常被描述为一把双刃剑。激活自噬或抑制自噬在创新治疗中得到广泛的应用。现在研究发现,一些骨形成蛋白(bone morphogenetic proteins,BMPs)是某些人类疾病的致病因素,而另一些与某些疾病有密切联系。自噬与BMPs 在同一疾病(如神经退行性变)中的表达是否存在一定的相关性还有待研究。在这篇综述中,我们分别概述了不同条件下的自噬的表达情况和相同条件下的BMPs 的表达,以期发现自噬与BMPs 表达之间的一些联系。自噬与BMPs 的信号通路中存在一定相关性。

关键词: 自噬, 骨形成蛋白, Wnt, Notch

Abstract:

Autophagy is often described as a double-edged sword in diseases. Strategies utilizing autophagy either for activating or inhibiting it could find a broad application for innovative treatment. Some of the bone morphogenetic proteins (BMPs) have been found to be causative factors for certain human disease,while others have been shown to have a strong association with other diseases. Whether there are some associations between autophagy and BMPs expression in the same disease such as neurodegeneration remains to be investigated. In this brief review,we summarized autophagy in different conditions and BMPs expression in the same conditions respectively in order to discover some associations between autophagy and BMPs expression. Some associations are found in signaling pathway of both autophay and BMPs.

Key words: autophay, bone morphogenetic proteins (BMPs), Wnt, Notch

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