牡丹中主要活性单体抗缺血性脑卒中研究进展

doi:10.3969/j.issn.2095-1396.2016.02.007

神经药理学报 ›› 2016, Vol. 6 ›› Issue (2): 37-45.DOI: 10.3969/j.issn.2095-1396.2016.02.007

牡丹中主要活性单体抗缺血性脑卒中研究进展

冯小叶，宋修云，陈乃宏

1. 中国医学科学院，药物研究所 & 神经科学中心，北京，100050，中国
2. 湖南中医药大学药学院，长沙，410208，中国

出版日期:2016-04-26 发布日期:2016-05-10
通讯作者: 陈乃宏，男，研究员，博士生导师；研究方向：神经药理学和神经分子生物学；Tel：+86-010-63165177，Fax：+86-010-63165211，E-mail：chennh@imm.ac.cn
作者简介:冯小叶，女，学士；E-mail：649201711@qq.com
基金资助:
国家自然科学基金项目（No.81274122、No.81373997、No.U1402221），国家“重大新药创制”科技重大专项（No.2012ZX09301002），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150）

Research Progress of Peony Main Active Monomers on Cerebral Ischemia

FENG Xiao-ye，SONG Xiu-yun，CHEN Nai-hong

1. Chinese Academy of Medical Science and Peking Union Medical College，Beijing，100050，China
2. School of Pharmacy，Hunan University of Chinese Medicine，Changsha，410208，China

Online:2016-04-26 Published:2016-05-10
Contact: 陈乃宏，男，研究员，博士生导师；研究方向：神经药理学和神经分子生物学；Tel：+86-010-63165177，Fax：+86-010-63165211，E-mail：chennh@imm.ac.cn
About author:冯小叶，女，学士；E-mail：649201711@qq.com
Supported by:
国家自然科学基金项目（No.81274122、No.81373997、No.U1402221），国家“重大新药创制”科技重大专项（No.2012ZX09301002），新药作用机制研究与药效评价北京市重点实验室资助项目（No.BZ0150）

摘要/Abstract

摘要： 缺血性脑卒中具有高发病率、高致死率和高致残率的特点，是严重威胁人类健康的常见疾病之一。中药治疗缺血性脑卒中是中医药学历代积累下来的宝贵财富。牡丹是毛茛科芍药属植物，主要活性部位为牡丹皮和种子，尤其是牡丹皮。中医理论认为，牡丹皮是活血化瘀的良药。现代药理学研究发现，多种牡丹提取单体对缺血性脑卒中具有显著改善作用，提示牡丹活性提取物作为缺血性脑疾病的潜在治疗药物，具有广阔的开发前景和临床应用价值。因此，该文综述近年来牡丹中主要活性单体抗缺血性脑卒中研究进展。

关键词: 牡丹, 缺血性脑卒中, 药理

Abstract: Cerebral ischemic stroke which has characteristics of high morbidity，high mortality and high disability，is a kind of common diseases that threaten human health. It’s the precious wealth which is accumulated by ancient Chinese to treat cerebral ischemia with traditional Chinese medicine. The peony belongs to Paeonia L. of Ranunculaceae. The main active parts of peony are the root bark and seeds，especially the root bark. According to the theory of Chinese medicine，the root bark of peony is a kind of efficient drugs in promoting blood circulation and removing blood stasis. What’s more，modern pharmacological studies find that a variety of peony extract monomers have marked effects on improving cerebral ischemia stroke，which suggest that these monomers may be the potential drugs to treat ischemic cerebrovascular disease. And these peony extract monomers have the value of deep research and clinical application. Therefore，this paper reviewed the research progress of the main active monomers of peony on the effects of anti-cerebral ischemia stroke in recent years.

Key words: peony, cerebral ischemic stroke, pharmacology

中图分类号:

R285，R964

冯小叶，宋修云，陈乃宏. 牡丹中主要活性单体抗缺血性脑卒中研究进展[J]. 神经药理学报, 2016, 6(2): 37-45.

FENG Xiao-ye，SONG Xiu-yun，CHEN Nai-hong. Research Progress of Peony Main Active Monomers on Cerebral Ischemia[J]. Acta Neuropharmacologica, 2016, 6(2): 37-45.

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牡丹中主要活性单体抗缺血性脑卒中研究进展

Research Progress of Peony Main Active Monomers on Cerebral Ischemia

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