Although ginsenoside CK (CK) has pharmacological potential, it needs to be transformed into practical dosage forms via pharmaceutical formulation technology to improve efficacy, reduce toxic and side effects, and promote its translation from active ingredient to clinical application. With the development of pharmaceutics, novel dosage forms have driven further advances in the research of CK formulations. This paper systematically reviews the research status of CK in passive targeting, active targeting, physicochemical property-responsive and non-targeted delivery systems by classifying according to delivery systems, analyzes the existing problems in current research, and provides new ideas and references for the development and clinical application of CK formulations.