神经药理学报

神经药理学报 ›› 2026, Vol. 16 ›› Issue (1): 28-.DOI: 10.3969/j.issn.2095-1396.2026.01.005

• 综述 • 上一篇    下一篇

雌激素及雌激素受体在女性疾病中的研究进展

刘延曼，李文娟，董逢夏，刘春薇，侯雪芹   

  1. 山东第一医科大学（山东省医学科学院）药学院，济南，250117，中国
  • 出版日期:2026-03-02 发布日期:2026-05-07
  • 作者简介:刘延曼，女，硕士研究生；研究方向：神经药理学
  • 基金资助:
    国家自然科学基金项目（No.82274235），山东省重点研发项目（No.2019GSF108069）

Research Progress of Estrogen and Estrogen Receptor in Female Diseases

LIU Yan-man，LI Wen-juan，DONG Feng-xia，LIU Chun-wei，HOU Xue-qin   

  1. College of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China
  • Online:2026-03-02 Published:2026-05-07

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摘要：

雌激素是女性非常重要的性激素，主要由女性卵巢产生，在体内与雌激素受体（estrogen receptor，ER） 结合发挥生物学效应。近年来研究发现，雌激素及其受体不仅能促进女性生殖器官的发育，还具有中枢神经系 统的保护作用、抗骨质疏松、抑制肿瘤和改善代谢性疾病等作用。该文通过回顾并总结雌激素及其受体在女性 疾病中的研究进展和植物雌激素的应用，以期为雌激素临床应用和新药研发提供依据。

关键词: 雌激素, 雌激素受体, 女性, 植物雌激素

Abstract:

Estrogen is a very important sex hormone in women. It is mainly produced by the female ovaries and has biological effects by binding with the estrogen receptor (ER) in vivo. In recent years, studies have found that estrogen and its receptors can not only promote the development of female reproductive organs, but also have the role of central nervous system protection, anti-osteoporosis, tumor inhibition and improvement of metabolic diseases. This article reviews and summarizes the research progress of estrogen and its receptors in female diseases and the application of phytoestrogens, in order to provide evidence for the clinical application of estrogen and the development of new drugs.

Key words: estrogen, estrogen receptor, female, phytoestrogens

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