神经药理学报

神经药理学报 ›› 2025, Vol. 15 ›› Issue (3): 7-.DOI: 10.3969/j.issn.2095-1396.2025.03.002

• 研究论文 • 上一篇    下一篇

头孢曲松钠致过敏性休克46例文献分析

张本常，王泽宇，乔廷廷，王禹，颜娟   

  1. 1. 河北北方学院药学院，河北省神经药理学重点实验室，张家口，075000，中国 

    2. 河北北方学院附属第一医院药物临床实验办公室，张家口，075000，中国

  • 出版日期:2025-06-26 发布日期:2025-07-10
  • 通讯作者: 颜娟，博士，副主任药师，硕士生导师；研究方向：肿瘤临床药学
  • 作者简介:张本常，硕士研究生；研究方向：临床药学；E-mail：zhangbenchang2024@163.com
  • 基金资助:
    河北省自然科学基金项目（No.H2021405002），张家口市重点研发计划项目（No.2221108D）

Literature Analysis of 46 Cases of Allergic Shock Caused by Ceftriaxone Sodium

ZHANG Ben-chang, WANG Ze-yu, QIAO Ting-ting, WANG Yu, YAN Juan   

  1. 1. College of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China 

    2. Good Clinical Practice Office, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

  • Online:2025-06-26 Published:2025-07-10

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摘要：

目的：对头孢曲松钠诱发过敏性休克的临床特点和规律进行分析，为保障临床用药安全提供依据。方法： 对2011—2024 年度国内外公开发表的头孢曲松钠致过敏性休克的文献进行检索，筛选出头孢曲松钠致过敏性休 克的个案报告并进行回顾性分析。结果：共检索出46 例头孢曲松钠致过敏性休克报告，在这些病例中，首次用药 期间出现过敏性休克的病例占73.9%，连续用药后出现过敏性休克的病例占26.1%，在皮试过程中有4 例出现过 敏性休克。结论：临床应用头孢曲松钠需严格遵循诊疗规范，针对患者个体差异制定个体化用药方案，监测患者 个体生命体征，并建立急性过敏反应应急处理预案，确保患者用药安全。

关键词: 过敏性休克, 头孢曲松钠, 用药安全

Abstract:

Objective： To analyze the clinical characteristics and patterns of allergic shock induced by ceftriaxone sodium, and provide a basis for ensuring the safety of clinical medication. Methods: A search was conducted on the literature on ceftriaxone sodium induced anaphylactic shock published domestically and internationally from 2011 to 2024. Case reports of ceftriaxone sodium induced anaphylactic shock were selected and retrospectively analyzed. Results: A total of 46 cases of allergic shock caused by ceftriaxone sodium were retrieved. Among these cases, 73.9% experienced allergic shock during the first use of the drug, 26.1% experienced allergic shock after continuous use, and 4 cases experienced allergic shock during skin testing; The overall mortality rate reached 10.8%. Conclusion: The clinical application of ceftriaxone sodium requires strict adherence to diagnostic and treatment standards, individualized medication plans tailored to individual patient differences, monitoring of individual vital signs, and establishment of emergency response plans for acute allergic reactions to ensure patient medication safety.

Key words: anaphylactic shock, ceftriaxone sodium, medication safety

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