神经药理学报

神经药理学报 ›› 2023, Vol. 13 ›› Issue (3): 60-.DOI: 10.3969/j.issn.2095-1396.2023.03.010

• 综述 • 上一篇    

术前衰弱与围术期发生不良事件的相关性

李向博，黄予利，袁莉，滕金亮   

  1. 1 河北北方学院研究生学院，张家口，075000，中国 

    2 河北北方学院附属第一医院麻醉科，张家口，075000，中国

  • 出版日期:2023-06-26 发布日期:2024-05-09
  • 通讯作者: 滕金亮，主任医师，教授，研究生导师
  • 作者简介:李向博，2021级硕士研究生；E-mail: 891320786@qq.com
  • 基金资助:
    张家口市重点研发计划项目（2201146D）

Association Between Preoperative Frailty and Perioperative Adverse Events

LI Xiang-bo，HUANG Yu-li，YUAN Li，TENG Jin-liang   

  1. 1.The Graduate School of Hebei North University, 075000, Zhangjiakou, China 

    2.Department of Anesthesiology, The first clinical college of Hebei North University, 075000, Zhangjiakou, China

  • Online:2023-06-26 Published:2024-05-09
  • Contact: 滕金亮，主任医师，教授，研究生导师
  • About author:李向博，2021级硕士研究生；E-mail: 891320786@qq.com

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摘要：

老年人术前衰弱是影响围术期康复最严重的挑战之一。术前衰弱状态会导致围术期出现各种不利事件，如住院时间延长、术后疼痛、术后抑郁、术后谵妄等。目前术前衰弱与围术期不良事件之间的关联机制尚不清楚，但存在多种系统功能失调的可能性较大。通过对术前衰弱的全面评估、及时干预和治疗可以显著降低围手术期出现的各种不良事件的发生。该文选择住院时间延长、术后认知功能障碍、术后抑郁及术后疼痛等较为典型的围术期不良事件，从术前衰弱与围术期不良事件的关系、可能相关的的发生机制及干预策略等角度予以综述。

关键词: 术前衰弱, 麻醉相关不良事件, 发生机制, 干预策略

Abstract:

Preoperative frailty is one of the most common clinical problems in perioperative elderly patients. Many studies have shown that preoperative frailty is closely related to the occurrence of perioperative adverse events, such as prolonged hospital stay, postoperative pain, postoperative depression, postoperative delirium, etc. The mechanism of preoperative frailty and perioperative adverse events is not fully understood at present, which may be related to the dysfunction of multiple system functions. Reasonable evaluation, intervention or treatment for preoperative frailty may help to reduce the occurrence of perioperative adverse events. In this paper, typical perioperative adverse events such as prolonged hospital stay, postoperative cognitive dysfunction, postoperative depression and postoperative pain were selected, and the relationship between preoperative frailty and perioperative adverse events, possible related mechanisms and intervention strategies were reviewed.

Key words: frailty before surgery, anaesthesia-related adverse events, mechanism of occurrence, strategy of intervention