神经药理学报 ›› 2022, Vol. 12 ›› Issue (3): 28-.DOI: 10.3969/j.issn.2095-1396.2022.03.006

• 综述 • 上一篇    下一篇

皮层扩散性抑制的研究进展

赵博,禹爱梅,邹玉安   

  1. 1 河北北方学院研究生学院,张家口,075000,中国  2 河北北方学院附属第一医院神经内科,张家口,075000,中国
  • 出版日期:2022-06-26 发布日期:2022-06-26
  • 通讯作者: 邹玉安,主任医师,硕士研究生导师;E-mail:baiyitiansho@163.com
  • 作者简介:赵博,在读研究生;研究方向:神经病学;E-mail:18131374605@163.com

Research Progress of Cortical Spreading Depression

ZHAO Bo,YU Ai-mei,ZOU Yu-an   

  1. 1. Graduate School,Hebei North University,Zhangjiakou,075000,China  2. The First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China
  • Online:2022-06-26 Published:2022-06-26

摘要:

皮质扩散性抑制(cortical spreading depression,CSD)是大脑皮质受刺激后产生的电活动抑制带,该抑 制带可以将大脑皮质跨膜离子的浓度梯度迅速摧毁并去极化,导致细胞内外发生短路,可以影响大脑的灌注及 代谢,导致不良预后,该文将从以下几个方面对CSD 的研究进展进行综述。

关键词: 皮层扩散性抑制, 去极化, 低灌注

Abstract:

Cortical spreading depression is an inhibitory band of electrical activity generated after the cerebral cortex is stimulated. This inhibitory band can rapidly destroy and depolarize the concentration gradient of transmembrane ions in the cerebral cortex,resulting in short circuits inside and outside cells,which can affect brain perfusion and metabolism.resulting in a poor prognosis. This paper will summarize the research progress of CSR from the following aspects.

Key words: cortical spreading depression, depolarization, low flow perfusion

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