缺血缺氧预适应对抗脑缺血缺氧损伤的机制研究进展

摘要/Abstract

摘要： 缺血缺氧预适应现象最初见于心脏，一经发现即引起了学术界的广泛关注，随后研究者分别从不同层面证实了大脑同样具有预适应现象，并进行了大量的研究，成为抗脑缺血缺氧研究的热点。脑缺血缺氧预适应（cerebral ischemia/hypoxia preconditioning，CIP）可以通过多种信号传导途径，减少细胞凋亡，提高机体抗氧化能力，减少氧化损伤，升高低氧诱导因子和热休克蛋白HSP70的生成等，各种机制相互联接，相对独立。

关键词: 缺血缺氧预适应, 细胞凋亡, 活性氧, 信号传导, 低氧诱导因子, 热休克蛋白质类

Abstract: The phenomenona of ischemia/hypoxia preconditioning were first discovered in heart. Numerous studies，carried out at different levels，have confirmed that there are also preconditioning phenomenona in brain，and the phenomenona of ischemia/hypoxia preconditioning in brain have become a hot topic in the field of ischemia and hypoxia. Cerebral ischemia/hypoxia preconditioning (CIP) can decrease cell apoptosis，increase the anti-oxidant ability and decrease oxidant injury，increase the generation of hypoxic inducible factor-1 and heat shock protein 70 through multiple signal transduction pathways. There are interactions among the mechanisms about CIP which are relatively independent.

Key words: ischemia hypoxia preconditioning, apoptosis, reactive oxygen species, signal transduction, hypoxic inducible factor, heat shock proteins

中图分类号:

R743

袁恒杰，娄建石. 缺血缺氧预适应对抗脑缺血缺氧损伤的机制研究进展[J]. 神经药理学报, 2011, 1(4): 42-47.

YUAN Heng-jie，LOU Jian-shi. Research Progress in the Mechanisms of Cerebral Ischemia Hypoxia Preconditioning Antagonizing Cerebral Ischemia and Hypoxia Injury[J]. Acta Neuropharmacologica, 2011, 1(4): 42-47.

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