摘要： Objectives：Huperzine A tablet has been approved as a treatment for Alzheimer disease and benign memory disorder in china for many years. But the pharmacokinetics characteristic remains indeterminacy，especially in elderly patients. This study aimed to investigate the pharmacokinetic properties and tolerability of huperzine A tablet in healthy elderly Chinese subjects. Methods：This was an open-label，randomized，single dose study in fourteen aged 60~80 years elderly Chinese subjects. A series of plasma and urine samples were collected and used to determine the concentrations of huperzine A by a liquid chromatography-tandem mass spectrometric method. Safety and tolerance were determined by clinical evaluation and monitoring adverse events. Results：Huperzine A was rapidly absorbed with mean Tmax of 2 hours and tardily cleared with T1/2 approximately 14 hours. Cmax was a little lower than that of young subjects，otherwise AUC was higher in elderly subjects. The main pharmacokinetic parameters of huperzine A were similar between males and females except Tmax. There were no SAEs reported and no withdrawals due to AEs. Conclusions：Huperzine A was well tolerated by healthy elderly Chinese subject and exhibits a different pharmacokinetic profi le from young subjects.

关键词: huperzine A, elderly subjects, pharmacokinetics, safety