神经药理学报 ›› 2012, Vol. 2 ›› Issue (4): 58-64.

• 综述 • 上一篇    

丹参有效成分丹参酮IIA和丹酚酸A药理学研究进展

金灿, 张丹参   

  1. 1. 河北北方学院药学系,张家口,075000,中国
    2. 河北科技大学,石家庄,050018,中国
  • 出版日期:2012-08-26 发布日期:2014-06-27
  • 通讯作者: 张丹参,女,教授,博士生导师;研究方向:神经药理学;Tel:+86-0311-81668016,E-mail:zhangds2011@126.com
  • 作者简介:金灿,女,研究生;E-mail:cking5168@163.com
  • 基金资助:

    国家自然科学基金项目(No.81274005),河北省自然科学基金项目(No.C2009001026)

Research Progress of The Effective Ingredients of Radix Salviae Miltiorrhizae, Tanshinone IIA and Salvianolic Acid A

JIN Can, ZHANG Dan-shen   

  1. 1.      Department of Pharmacology,Hebei North University,Zhangjiakou,075000, China
    2.      Hebei University of Science and Technology,Shijiazhuang,050018,China
  • Online:2012-08-26 Published:2014-06-27
  • Contact: 张丹参,女,教授,博士生导师;研究方向:神经药理学;Tel:+86-0311-81668016,E-mail:zhangds2011@126.com
  • About author:金灿,女,研究生;E-mail:cking5168@163.com
  • Supported by:

    国家自然科学基金项目(No.81274005),河北省自然科学基金项目(No.C2009001026)

摘要: 丹参具有抗氧化,抗凝血,抗肿瘤等作用,含有多种有效成分,目前国内外对丹参单体的研究已较为深入,利用先进的现代生物学技术对单体药物的作用机制及作用靶点进行研究的报道也较为多见。丹参有效成分主要分为脂溶性的丹参酮类和水溶性的丹酚酸类,本文将对丹参脂溶性有效单体丹参酮II A和水溶性有效单体丹酚酸A的近期药理作用研究进展进行综述。

关键词: 丹参, 丹参酮IIA, 丹酚酸A

Abstract: Many studies have showed that Radix Salviae Miltiorrhizae(RSM),with multi-ingredients, has effects of antioxidant, anti-clotting and antitumor. Currently, the studies on RSM monomers have been more in-depth. Using modern biology approaches, increasing reports are concerning the mechanism and the targets of these ingredients. RSM active ingredients are mainly divided into fat-soluble tanshinones and water-soluble dan phenolic acids. Recent pharmacological findings of tanshinone II A (fat-soluble) and Salvianolic acid A (water-soluble) were reviewed.

Key words: radix salviae miltiorrhizae, tanshinone II A, salvianolic acid A

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